Determination of bupropion and hydroxybupropion by LC-MS/MS in rat and its application to assessment of CYP2B6 activity
A selective and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for quantitation of bupropion (BUP) and its metabolite hydroxybupropion (HBUP) in rat plasma and urine using carbamazepine as an internal standard. Chromatographic separation was achieved on a...
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| Autores principales: | Pan, Xiaofeng, Xu, Zhisheng, Du, Xiaoxiang, Hu, Hufeng, Fei, Ai-li, Wang, Zhe, Xu, Ren-ai |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/25697 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_10.pdf |
| Aporte de: |
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