Strong Inhibition of UDP-Glucuronosyltransferase (UGT) 1A1 by Levothyroxine Indicates the Potential UGT-Inhibition Based Adverse Effect of Levothyroxine

UDP-glucuronosyltransferase (UGT) 1A1, one of the most important UGT isoforms, can metabolize a variety of endogenous substances and xenobiotics. UGT1A1-catalyzed glucuronidation reaction plays a key role in many clinical events, including Gilbert syndrome and irrinotecan-induced diarrhea toxicity....

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Detalles Bibliográficos
Autores principales: Zhao, Hua-Dong, Bao, Guo-Qiang, He, Xian-Li, Wu, Tao, Wang, Cheng-Guo, Wang, Sheng-Zhi, Zang, Li, Lu, Jian-Guo, Du, Xi-Lin
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Glucuronosiltransferasa
Levothyroxine
UDP-glucuronosyltransferase (UGT) 1A1
Drug-drug interaction
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20236
http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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