Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity

New complexes of platinum and palladium were isolated with 2,4-dinitrophenylhydrazine (2,4-DNPH). These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH2 group and have the general structure cis-[M(2,4- DNPH)2Cl2 ]...

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Detalles Bibliográficos
Autores principales: Souza, Gustavo D. de, Fernandes, Lucianno E., Rodrigues, Mônica A., Silva, Priscila P., Pereira-Maia, Elene C., Guerra, Wendell
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Cytotoxic activity
Hydrazones
Metal-based drugs
Platinum complexes
Paladio
Hidrazonas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20207
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:New complexes of platinum and palladium were isolated with 2,4-dinitrophenylhydrazine (2,4-DNPH). These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH2 group and have the general structure cis-[M(2,4- DNPH)2Cl2 ].H2O where M = Pt or Pd. The thermal stability of the complexes was followed in the temperature range 25-850 ºC. The antitumor activity of the synthesized compounds has been studied and the compound cis-[Pt(2,4-DNPH)2Cl2 ], was found to display cytotoxicity (IC50 = 4.6 μmol/L) against K562 tumoral cell line. This work is the first to describe the cytotoxic activity of complexes containing 2,4-dinitrophenylhydrazine

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