Essential oil from eucalyptus benthamii Maiden et Cambage reduces nitric oxide production in lipopolysaccharide-induced murine peritoneal macrophages

Few studies are concerned about the essential oil extracted from leaves of Eucalyptus benthamii Maiden et Cambage that shows high content of α-pinene. The goal of this paper was to investigate the in vitro effect of the essential oil of E. benthamii and α-pinene on lipopolysaccharide (LPS)-induced n...

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Detalles Bibliográficos
Autores principales: Döll-Boscardini, Patrícia M., Almeida, Martinha A., Nakashima, Tomoe, Paula, Josiane de F. Padilha de, Kanunfre, Carla C., Farago, Paulo V.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
aceite esencial
Óxido Nítrico
Myrtaceae
α-pinene
essential oil
eucalyptus benthamii
nitric oxide production
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20179
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_8.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Few studies are concerned about the essential oil extracted from leaves of Eucalyptus benthamii Maiden et Cambage that shows high content of α-pinene. The goal of this paper was to investigate the in vitro effect of the essential oil of E. benthamii and α-pinene on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages. Macrophages were harvested by washing with phosphate buffered saline and cultured with 10 μg/mL LPS. Three concentrations (5, 10, and 20 μg/mL) of the essential oil of E. benthamii and α-pinene were investigated. Nitrite levels were measured based on the Griess reaction, an indirect assay for NO production. The essential oil of E. benthamii significantly suppressed NO production in murine peritoneal macrophages at 10 and 20 μg/mL. In contrast, α-pinene did not inhibit NO production.

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