Simultaneous determination of midazolam and 1’-hydroxymidazolam in rat plasma by protein precipitation and LC-MS: application to pharmacokinetic study
A sensitive and selective liquid chromatography–mass spectrometry (LC–MS) method for determination of midazolam and its metabolite 1’-hydroxymidazolam in rat plasma was developed and validated. After addition of carbamazepine as internal standard (IS), protein precipitation by acetonitrile was used...
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| Autores principales: | Chen, Xiaole, Xu, Tao, Wang, Zhe, Pan, Peipei, Luo, Shunbing, Lin, Dan, Hu, Guoxin, Pan, Jianchun |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/20174 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_6.pdf |
| Aporte de: |
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