Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats

The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of gambogenic acid (GNA), potential antitumor candidate, were investigated in rats. GNA showed linear pharmacokinetic characteristics in rats within the test dose (1, 2, and 4 mg/kg). The t1/2β was 40.38-41.16 min. GNA showe...

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Detalles Bibliográficos
Autores principales: Wang, Dianlei, Zhang, Rui, Peng, Daiyin, Chen, Weidong, Zhou, An, Wang, Xiaoshan, Li, Qinglin
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Farmacocinética
Distribución Tisular
Modalidades de Secreciones y Excreciones
Ratas
Excretion
Gambogenic acid
Metabolism
Pharmacokinetics
Tissue distribution
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20171
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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