Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits
The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) a...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/18126 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf |
| Aporte de: | Aportado por :
SEDICI (UNLP) de
Universidad Nacional de La Plata .
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| id |
I19-R120-10915-18126 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Fenómenos Bioquímicos cefepime; pharmacokinetics; rabbits; safety Farmacocinética |
| spellingShingle |
Farmacia Fenómenos Bioquímicos cefepime; pharmacokinetics; rabbits; safety Farmacocinética Rule, Roberto Petinelli, A. Cordiviola, Carlos Ángel Prozzi, Guillermo Rafael Farina, Osvaldo Hugo Villagra, Sergio Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits |
| topic_facet |
Farmacia Fenómenos Bioquímicos cefepime; pharmacokinetics; rabbits; safety Farmacocinética |
| description |
The aim of this study was to determine the kinetic behaviour and the safety of cefepime administered to rabbits. For this, rabbits (n = 29) were used and distributed in Groups 1 (G1), 2 (G2) and Control (CG). Animals from G1 (n = 21) received a monodose of cefepime intravenously, (20 mg/kg weight) and, after this, blood samples were collected, controlling the time. Rabbits from Group G2 (n = 4) received multidoses of cefepime (20 mg/kg weight, intravenously), and blood and urine samples were taken in order to analyse them. Animals from Groups G2 and CG were controlled electrocardiographically (ECG) throughout the treatment. Rabbits from Group CG (n = 4) were evaluated and samples were obtained in the same way and within the same time periods as G2. The concentration-time curves of cefepime were determined using a biological method, and it was analysed through a non-compartmental model. The pharmacokinetic results (Mean ± S.D.) were: t½ = 1.6 ± 0.4 h; AUC = 212.1 ± 82.1 μg/mL.h; AUMC = 387.4 ± 132.2 μg/mL.h; Vss = 216.7 ± 63.4 mL/kg; CL = 99.7 ± 19.4 mL/kg y TMR = 2.0 ± 0.4 h. The cefepime administered to rabbits in therapeutic doses did not produce any biochemical, electrocardiographic or renal modification. |
| format |
Articulo Articulo |
| author |
Rule, Roberto Petinelli, A. Cordiviola, Carlos Ángel Prozzi, Guillermo Rafael Farina, Osvaldo Hugo Villagra, Sergio |
| author_facet |
Rule, Roberto Petinelli, A. Cordiviola, Carlos Ángel Prozzi, Guillermo Rafael Farina, Osvaldo Hugo Villagra, Sergio |
| author_sort |
Rule, Roberto |
| title |
Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits |
| title_short |
Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits |
| title_full |
Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits |
| title_fullStr |
Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits |
| title_full_unstemmed |
Pharmacokinetics and Evaluation of the Safety of Cefepime Administered to Rabbits |
| title_sort |
pharmacokinetics and evaluation of the safety of cefepime administered to rabbits |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/18126 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_17.pdf |
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AT ruleroberto pharmacokineticsandevaluationofthesafetyofcefepimeadministeredtorabbits AT petinellia pharmacokineticsandevaluationofthesafetyofcefepimeadministeredtorabbits AT cordiviolacarlosangel pharmacokineticsandevaluationofthesafetyofcefepimeadministeredtorabbits AT prozziguillermorafael pharmacokineticsandevaluationofthesafetyofcefepimeadministeredtorabbits AT farinaosvaldohugo pharmacokineticsandevaluationofthesafetyofcefepimeadministeredtorabbits AT villagrasergio pharmacokineticsandevaluationofthesafetyofcefepimeadministeredtorabbits |
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Repositorios |
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