Calcium and TFAM crosstalk in the mitochondrial life cycle in cardiomyocytes
Calcium (Ca2+) links the electrical signals of the heart to the mechanical action of contraction in a process referred to as the cardiac excitation-contraction (EC) coupling, a process that consumes a large amount of adenosine triphosphate (ATP). The majority of ATP is produced in the mitochondria v...
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| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/163606 |
| Aporte de: |
| Sumario: | Calcium (Ca2+) links the electrical signals of the heart to the mechanical action of contraction in a process referred to as the cardiac excitation-contraction (EC) coupling, a process that consumes a large amount of adenosine triphosphate (ATP). The majority of ATP is produced in the mitochondria via oxidative phosphorylation (OXPHOS), which is linked to Ca2+ flux. The OXPHOS system is regulated by both the nuclear and mitochondrial genome, with mitochondrial transcription factor A (TFAM) being a major regulator of the latter. This mini review focuses on summarizing the limited literature implicating crosstalk between Ca2+ and TFAM in the adult cardiomyocyte throughout the mitochondrial life cycle: mitochondrial dynamics, biogenesis, and mitophagy. The goal of this review is to highlight gaps and fuel further investigation of the proposed Ca2+-TFAM axis. This research area has high potential to propel the development of therapeutic strategies targeting cardiovascular diseases such as heart failure. |
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