HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina

Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladde...

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Autores principales: Moavro, Damián Ezequiel, Andrini, Laura Beatriz, Iribarne, Ailén, Colaci, Pablo Francisco, García, Marcela Nilda
Formato: Articulo
Lenguaje:Inglés
Publicado: 2023
Materias:
Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/162467
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-162467
record_format dspace
spelling I19-R120-10915-1624672024-02-08T04:44:38Z http://sedici.unlp.edu.ar/handle/10915/162467 HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina Moavro, Damián Ezequiel Andrini, Laura Beatriz Iribarne, Ailén Colaci, Pablo Francisco García, Marcela Nilda 2023-04-15 2024-02-07T18:29:10Z en Ciencias Médicas Transitional bladder carcinoma Human leukocyte antigen G Immunohistochemistry Prognostic factor Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful. Facultad de Ciencias Médicas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 423-427
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
spellingShingle Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
Moavro, Damián Ezequiel
Andrini, Laura Beatriz
Iribarne, Ailén
Colaci, Pablo Francisco
García, Marcela Nilda
HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
topic_facet Ciencias Médicas
Transitional bladder carcinoma
Human leukocyte antigen G
Immunohistochemistry
Prognostic factor
description Transitional carcinoma (TC) is the most common neoplasm of the bladder (80%). The immune checkpoint (IC) Human leukocyte antigen G (HLA‐G) expression has been demonstrated within numerous types of cancer and correlates with the degree of malignancy. This study aims for HLA‐G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. We study thirty TC samples, in which we determine the invasion level and the HLA‐G expression by immunohistochemistry. From all analyzed cases, 23 correspond to high‐grade TC, of whom 91% presented HLA‐G immunostaining and 83% compromised the muscularis propria layer of the bladder. Four patients in this group have not exceeded 5 years of survival. This data confirms that HLA‐G expression in the bladder TC is associated with greater aggressiveness. Therefore, adding this immunostaining to the immunohistochemical panel used in the routine diagnosis of this neoplasm would be very useful.
format Articulo
Articulo
author Moavro, Damián Ezequiel
Andrini, Laura Beatriz
Iribarne, Ailén
Colaci, Pablo Francisco
García, Marcela Nilda
author_facet Moavro, Damián Ezequiel
Andrini, Laura Beatriz
Iribarne, Ailén
Colaci, Pablo Francisco
García, Marcela Nilda
author_sort Moavro, Damián Ezequiel
title HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_short HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_full HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_fullStr HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_full_unstemmed HLA-G expression in transitional bladder carcinoma : Relationship with tumor invasion level and patient survival: Experience in a public hospital in Argentina
title_sort hla-g expression in transitional bladder carcinoma : relationship with tumor invasion level and patient survival: experience in a public hospital in argentina
publishDate 2023
url http://sedici.unlp.edu.ar/handle/10915/162467
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