Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats

Ageing is associated with impaired performance in recognition memory, a process that consists of the discrimination of familiar and novel stimuli. Previous studies have shown the impact of ageing on object recognition memories. However, the early stages of memory impairment remain unknown. To fill t...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Canatelli Mallat, Martina, Chiavellini, Priscila, Lehmann, Marianne, Goya, Rodolfo Gustavo, Morel, Gustavo Ramón
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Ciencias Médicas
Ageing rats
Spatial object recognition
Features object recognition
Perirhinal cortex
Hippocampus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151821
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151821
record_format dspace
spelling I19-R120-10915-1518212023-04-20T04:08:36Z http://sedici.unlp.edu.ar/handle/10915/151821 issn:0166-4328 Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats Canatelli Mallat, Martina Chiavellini, Priscila Lehmann, Marianne Goya, Rodolfo Gustavo Morel, Gustavo Ramón 2022 2023-04-19T18:40:30Z en Ciencias Médicas Ageing rats Spatial object recognition Features object recognition Perirhinal cortex Hippocampus Ageing is associated with impaired performance in recognition memory, a process that consists of the discrimination of familiar and novel stimuli. Previous studies have shown the impact of ageing on object recognition memories. However, the early stages of memory impairment remain unknown. To fill this gap, we aimed at evaluating the ability of young (Y), middle-aged (MA), and senile (S) female Sprague-Dawley rats to retain 24 h long-term recognition memory. The MA cohort was included to characterise early memory deficits under two behavioural paradigms based on spontaneous location recognition (SLR) and spontaneous object recognition (SOR) tasks. In the SLR task, there was a markedly diminished novel discrimination capacity in the MA and S rats compared with the Y ones. In the SOR task, S rats evidenced a deterioration in novelty discrimination, while MA rats partially preserved the capacity to distinguish the new stimulus as compared with Y rats. Regarding early changes from MA to S rats, immunohistochemistry showed a marked decrease in the number and diameter of adult-born immature neurons in the Dentate Gyrus (DG) with a positive correlation with behavioural performance in the SLR task. Furthermore, we found a slight reduction in CA3 mature neurons and a decrease in the number of total microglia in the perirhinal cortex (Prh) in MA and S rats as compared with Y rats. As regards changes that were only observed in S rats, we found an increase in the number of total and reactive microglia in CA3 and a reduction in the number of total microglia in the DG. We conclude that spatial discrimination capacity could be affected earlier than feature discrimination capacity. We suggest that early depletion of neurogenesis in MA rats is involved in object location recognition deficits, whereas the disruption of microglial homeostasis in the Prh could be associated with object feature discrimination capacity. Instituto de Investigaciones Bioquímicas de La Plata Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Ageing rats
Spatial object recognition
Features object recognition
Perirhinal cortex
Hippocampus
spellingShingle Ciencias Médicas
Ageing rats
Spatial object recognition
Features object recognition
Perirhinal cortex
Hippocampus
Canatelli Mallat, Martina
Chiavellini, Priscila
Lehmann, Marianne
Goya, Rodolfo Gustavo
Morel, Gustavo Ramón
Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats
topic_facet Ciencias Médicas
Ageing rats
Spatial object recognition
Features object recognition
Perirhinal cortex
Hippocampus
description Ageing is associated with impaired performance in recognition memory, a process that consists of the discrimination of familiar and novel stimuli. Previous studies have shown the impact of ageing on object recognition memories. However, the early stages of memory impairment remain unknown. To fill this gap, we aimed at evaluating the ability of young (Y), middle-aged (MA), and senile (S) female Sprague-Dawley rats to retain 24 h long-term recognition memory. The MA cohort was included to characterise early memory deficits under two behavioural paradigms based on spontaneous location recognition (SLR) and spontaneous object recognition (SOR) tasks. In the SLR task, there was a markedly diminished novel discrimination capacity in the MA and S rats compared with the Y ones. In the SOR task, S rats evidenced a deterioration in novelty discrimination, while MA rats partially preserved the capacity to distinguish the new stimulus as compared with Y rats. Regarding early changes from MA to S rats, immunohistochemistry showed a marked decrease in the number and diameter of adult-born immature neurons in the Dentate Gyrus (DG) with a positive correlation with behavioural performance in the SLR task. Furthermore, we found a slight reduction in CA3 mature neurons and a decrease in the number of total microglia in the perirhinal cortex (Prh) in MA and S rats as compared with Y rats. As regards changes that were only observed in S rats, we found an increase in the number of total and reactive microglia in CA3 and a reduction in the number of total microglia in the DG. We conclude that spatial discrimination capacity could be affected earlier than feature discrimination capacity. We suggest that early depletion of neurogenesis in MA rats is involved in object location recognition deficits, whereas the disruption of microglial homeostasis in the Prh could be associated with object feature discrimination capacity.
format Articulo
Articulo
author Canatelli Mallat, Martina
Chiavellini, Priscila
Lehmann, Marianne
Goya, Rodolfo Gustavo
Morel, Gustavo Ramón
author_facet Canatelli Mallat, Martina
Chiavellini, Priscila
Lehmann, Marianne
Goya, Rodolfo Gustavo
Morel, Gustavo Ramón
author_sort Canatelli Mallat, Martina
title Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats
title_short Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats
title_full Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats
title_fullStr Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats
title_full_unstemmed Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats
title_sort age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female sprague dawley rats
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/151821
work_keys_str_mv AT canatellimallatmartina agerelatedlossofrecognitionmemoryanditscorrelationwithhippocampalandperirhinalcortexchangesinfemalespraguedawleyrats
AT chiavellinipriscila agerelatedlossofrecognitionmemoryanditscorrelationwithhippocampalandperirhinalcortexchangesinfemalespraguedawleyrats
AT lehmannmarianne agerelatedlossofrecognitionmemoryanditscorrelationwithhippocampalandperirhinalcortexchangesinfemalespraguedawleyrats
AT goyarodolfogustavo agerelatedlossofrecognitionmemoryanditscorrelationwithhippocampalandperirhinalcortexchangesinfemalespraguedawleyrats
AT morelgustavoramon agerelatedlossofrecognitionmemoryanditscorrelationwithhippocampalandperirhinalcortexchangesinfemalespraguedawleyrats
_version_ 1765660030427725824

Ejemplares similares