Interaction of Zn with Losartan : Activation of Intrinsic Apoptotic Signaling Pathway in Lung Cancer Cells and Effects on Alkaline and Acid Phosphatases

A new losartan [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol zinc(II) complex [Zn(Los)Cl], was synthesized and characterized. The crystal structure was determined by x-ray diffraction methods. When aqueous solutions of the ligand and the metal were mixed, t...

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Detalles Bibliográficos
Autores principales:	Martínez, Valeria Romina, Aguirre, María Victoria, Todaro, Juan Santiago, Piro, Oscar Enrique, Echeverría, Gustavo Alberto, Naso, Luciana Gissella, Ferrer, Evelina Gloria, Williams, Patricia Ana María
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2018
Materias:	Ciencias Exactas Química Losartan Zinc coordination Enzymatic inhibition Anticancer mechanism
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/145282
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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