Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1

The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of eve...

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Detalles Bibliográficos
Autores principales: Cingolani, Horacio Eugenio, Pérez, Néstor Gustavo, Aiello, Ernesto Alejandro, Ennis, Irene Lucía, Garciarena, Carolina Denis, Villa Abrille, María Celeste, Dulce, Raúl Ariel, Caldiz, Claudia Irma, Yeves, Alejandra del Milagro, Correa, María Verónica, Nolly, Mariela Beatriz, Chiappe de Cingolani, Gladys Ethel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Ciencias Médicas
Cardiología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138480
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.

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