Genomic features of attenuated Junín virus vaccine strain candidate

Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and...

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Detalles Bibliográficos
Autores principales: Goñi, Sandra Elizabeth, Iserte, Javier Alonso, Ambrosio, Ana Maria, Romanowski, Víctor, Ghiringhelli, Pablo Daniel, Lozano, Mario Enrique
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Biología
Arenaviridae
Junin
Attenuation
Molecular markers
L RNA
Genomic
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138396
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.

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