Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations

Bisphosphonates (BPs) are drugs widely used in the treatment of various bone diseases. BPs localize to bone mineral, and their concentration in resorption lacunae could reach almost milimolar levels. Bone alkaline phosphatase (ALP) is a membrane-bound exoenzyme that has been implicated in bone forma...

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Detalles Bibliográficos
Autores principales:	Vaisman, Diego Natalio, McCarthy, Antonio Desmond, Cortizo, Ana María
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2005
Materias:	Ciencias Exactas Bisphosphonates bone-specific alkaline phosphatase magnesium Zinc chelation osteoblasts
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/136002
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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