New route for 1-substituted hydantoins
Alkytation reactions on hydantoins (I) lead smoothly to 3-alkyl derivatives; more rigorous conditions allow further substitution at position 1 provided the N1-H group is activated by an aryl group or an ethylenic bond attached to the adjacent C52,a. All the hitherto available methods for the not rea...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
1965
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/134790 |
| Aporte de: |
| Sumario: | Alkytation reactions on hydantoins (I) lead smoothly to 3-alkyl derivatives; more rigorous conditions allow further substitution at position 1 provided the N1-H group is activated by an aryl group or an ethylenic bond attached to the adjacent C52,a. All the hitherto available methods for the not readily accessible 3-unsubstituted-1-alkylhydantoins (IV) require placing the substituent at the appropriate nitrogen atom prior to the complete formation of the hydantoin system. |
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