Mesoscopic oscillations in a single-gene circuit without delay

It is well known that single-gene circuits with negative feedback loop can lead to oscillatory gene expression when they operate with time delay. In order to generate these oscillations many processes can contribute to properly timing such delay. Here we show that the time delay coming from the tran...

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Detalles Bibliográficos
Autores principales: Guisoni, Nara Cristina, Monteoliva, Diana, Diambra, Luis Aníbal
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Exactas
Física
single-gene circuits
oscillatory gene expression
cis-regulatory system
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/134782
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-134782
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Física
single-gene circuits
oscillatory gene expression
cis-regulatory system
spellingShingle Ciencias Exactas
Física
single-gene circuits
oscillatory gene expression
cis-regulatory system
Guisoni, Nara Cristina
Monteoliva, Diana
Diambra, Luis Aníbal
Mesoscopic oscillations in a single-gene circuit without delay
topic_facet Ciencias Exactas
Física
single-gene circuits
oscillatory gene expression
cis-regulatory system
description It is well known that single-gene circuits with negative feedback loop can lead to oscillatory gene expression when they operate with time delay. In order to generate these oscillations many processes can contribute to properly timing such delay. Here we show that the time delay coming from the transitions between internal states of the cis-regulatory system (CRS) can drive sustained oscillations in an auto-repressive single-gene circuit operating in a small volume like a cell. We found that the cooperative binding of repressor molecules is not mandatory for a oscillatory behavior if there are enough binding sites in the CRS. These oscillations depend on an adequate balance between the CRS kinetic, and the synthesis/degradation rates of repressor molecules. This finding suggest that the multi-site CRS architecture plays a key role for oscillatory behavior of gene expression.
format Articulo
Articulo
author Guisoni, Nara Cristina
Monteoliva, Diana
Diambra, Luis Aníbal
author_facet Guisoni, Nara Cristina
Monteoliva, Diana
Diambra, Luis Aníbal
author_sort Guisoni, Nara Cristina
title Mesoscopic oscillations in a single-gene circuit without delay
title_short Mesoscopic oscillations in a single-gene circuit without delay
title_full Mesoscopic oscillations in a single-gene circuit without delay
title_fullStr Mesoscopic oscillations in a single-gene circuit without delay
title_full_unstemmed Mesoscopic oscillations in a single-gene circuit without delay
title_sort mesoscopic oscillations in a single-gene circuit without delay
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/134782
work_keys_str_mv AT guisoninaracristina mesoscopicoscillationsinasinglegenecircuitwithoutdelay
AT monteolivadiana mesoscopicoscillationsinasinglegenecircuitwithoutdelay
AT diambraluisanibal mesoscopicoscillationsinasinglegenecircuitwithoutdelay
bdutipo_str Repositorios
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