Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<...

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Detalles Bibliográficos
Autores principales:	Urquiza, Nora M., Manca, Silvia G., Moyano, María Alejandra, Dellmans, Raquel Arrieta, Lezama, Luis, Rojo, Teófilo, Naso, Luciana Gissella, Williams, Patricia Ana María, Ferrer, Evelina Gloria
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/133155
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

Descripción
Sumario:	Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.