Intracerebroventricular streptozotocin induces impaired Barnes maze spatial memory and reduces astrocyte branching in the CA1 and CA3 hippocampal regions

Sporadic Alzheimer’s disease (SAD) is the most common form of dementia; therefore, there is an urgent need for a model that recapitulates the main pathologic hallmarks of this disease. The intracerebroventricular (icv) injection of streptozotocin (icv-STZ) in rats constitutes a promising model, and...

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Guardado en:
Detalles Bibliográficos
Autores principales: Zappa Villar, María Florencia, López Hanotte, Juliette, Falomir Lockhart, Eugenia, Tripodi, Lucia, Morel, Gustavo Ramón, Reggiani, Paula Cecilia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Sporadic Alzheimer’s disease
Non-transgenic rat model
Streptozotocin
Spatial memory
Astrocyte-branching complexity
Hippocampal morphology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131995
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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