QSPR modeling of the enthalpy of formation based on Partial Order Ranking

A new predictive method based on Partial Order Ranking is introduced in the realm of the QSPR–QSAR Theory using a single descriptor as variable and which is simple enough to perform calculations by hand. Comparisons are made with a model relying on the Least Squares Method subjected to the modeling...

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Detalles Bibliográficos
Autores principales: Castro, Eduardo Alberto, Fernández, Francisco Marcelo, Duchowicz, Pablo Román
Formato: Articulo
Lenguaje:Inglés
Publicado: 2005
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Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/130947
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Sumario:A new predictive method based on Partial Order Ranking is introduced in the realm of the QSPR–QSAR Theory using a single descriptor as variable and which is simple enough to perform calculations by hand. Comparisons are made with a model relying on the Least Squares Method subjected to the modeling of the Enthalpy of Formation from Elements exhibed by a set of 51 hydrocarbon molecules by means of a flexible type descriptor. The results achieved with the proposed method are quite satisfactory and its future aplicability seems to be very promising.