Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat
There have been few studies of the pharmacodynamics of nonsteroidal antiinflammatory drugs (NSAIDs) using PK–PD modelling, yet this approach offers the advantage of defining the whole concentration–effect relationship, as well as its time course and sensitivity. In this study, ketoprofen (KTP) was a...
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2003
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/129263 |
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I19-R120-10915-129263 |
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dspace |
| institution |
Universidad Nacional de La Plata |
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I-19 |
| repository_str |
R-120 |
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SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Veterinarias Ketoprofen Pharmacokinetics Pharmacodynamics Goat Nonsteroidal antiinflammatory drugs |
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Ciencias Veterinarias Ketoprofen Pharmacokinetics Pharmacodynamics Goat Nonsteroidal antiinflammatory drugs Arifah, A. K. Landoni, María Fabiana Lees, Peter Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat |
| topic_facet |
Ciencias Veterinarias Ketoprofen Pharmacokinetics Pharmacodynamics Goat Nonsteroidal antiinflammatory drugs |
| description |
There have been few studies of the pharmacodynamics of nonsteroidal antiinflammatory drugs (NSAIDs) using PK–PD modelling, yet this approach offers the advantage of defining the whole concentration–effect relationship, as well as its time course and sensitivity. In this study, ketoprofen (KTP) was administered intravenously to goats as the racemate (3.0 mg/kg total dose) and as the single enantiomers, S(+) KTP and R(−) KTP (1.5 mg/kg of each). The pharmacokinetics and pharmacodynamics of KTP were investigated using a tissue cage model of acute inflammation. The pharmacokinetics of both KTP enantiomers was characterized by rapid clearance, short mean residence time (MRT) and low volume of distribution. The penetration of R(−) KTP into inflamed (exudate) and noninflamed (transudate) tissue cage fluids was delayed but area under the curve values were only slightly less than those in plasma, whereas MRT was much longer. The S(+) enantiomer of KTP penetrated less readily into exudate and transudate. Unidirectional inversion of R(−) to S(+) KTP occurred. Both rac-KTP and the separate enantiomers produced marked inhibition of serum thromboxane B2 (TxB2) synthesis (ex vivo) and moderate inhibition of exudate prostaglandin E2 (PGE2) synthesis (in vivo); pharmacodynamic variables for S(+) KTP were Emax (%) = 94 and 100; IC50 (μg/mL) = 0.0033 and 0.0030; N = 0.45 and 0.58, respectively, where Emax is the maximal effect, IC50 the plasma drug concentration producing 50% of Emax and N the slope of log concentration/effect relationship. The IC50 ratio, serum TxB2:exudate PGE2 was 1.10. Neither rac-KTP nor the individual enantiomers suppressed skin temperature rise at, or leucocyte infiltration into, the site of acute inflammation. These data illustrate for KTP shallow concentration–response relationships, probable nonselectivity of KTP for cyclooxygenase (COX)-1 and COX-2 inhibition and lack of measurable effect on components of inflammation. |
| format |
Articulo Articulo |
| author |
Arifah, A. K. Landoni, María Fabiana Lees, Peter |
| author_facet |
Arifah, A. K. Landoni, María Fabiana Lees, Peter |
| author_sort |
Arifah, A. K. |
| title |
Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat |
| title_short |
Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat |
| title_full |
Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat |
| title_fullStr |
Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat |
| title_full_unstemmed |
Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat |
| title_sort |
pharmacodynamics, chiral pharmacokinetics and pk–pd modelling of ketoprofen in the goat |
| publishDate |
2003 |
| url |
http://sedici.unlp.edu.ar/handle/10915/129263 |
| work_keys_str_mv |
AT arifahak pharmacodynamicschiralpharmacokineticsandpkpdmodellingofketoprofeninthegoat AT landonimariafabiana pharmacodynamicschiralpharmacokineticsandpkpdmodellingofketoprofeninthegoat AT leespeter pharmacodynamicschiralpharmacokineticsandpkpdmodellingofketoprofeninthegoat |
| bdutipo_str |
Repositorios |
| _version_ |
1764820452223483905 |