Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814
Mice with constitutive pseudo-phosphorylation at Ser2814-RyR2 (S2814D⁺<sup>/</sup>⁺) have increased propensity to arrhythmias under β-adrenergic stress conditions. Although abnormal Ca²⁺ release from the sarcoplasmic reticulum (SR) has been linked to arrhythmogenesis, the role played by...
Guardado en:
| Autores principales: | Mazzocchi, Gabriela, Sommese, Leandro Matías, Palomeque, Julieta, Felice, Juan Ignacio, Di Carlo, Mariano Nahuel, Fainstein, D., González, P. N., Contreras, Paola, Skapura, Darlene G., McCauley, Mark D., Lascano, Elena C., Negroni, Jorge A., Kranias, Evangelia G., Wehrens, Xander H. T., Valverde, Carlos Alfredo, Mattiazzi, Alicia Ramona |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/127243 |
| Aporte de: |
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