Efectos del tratamiento con N-acetil-cisteína en ratas tratadas con una dieta rica en fructosa: ¿reversión o prevención?

Introduction: Fructose overload promotes oxidative stress (OE) that induces metabolic damage, hepatic IR and local inflammatory response, alterations similar to those observed in human MS. NAC (N-acetyl-cysteine) has antioxidant capacity, provides substrates for the synthesis of GSH and has a high a...

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Guardado en:
Detalles Bibliográficos
Autores principales: Castro, María Cecilia, Villagarcía, Hernán Gonzalo, Nazar, Ada Paula, Massa, María Laura, Francini, Flavio
Formato: Articulo Comunicacion
Lenguaje:Español
Publicado: 2020
Materias:
Ciencias Médicas
Internal medicine
Endocrinology
Chemistry
Oxidative stress
Fructose
Tbars
Glycogen
Fructokinase
Uric acid
Glutathione
Glucokinase
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/126716
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Introduction: Fructose overload promotes oxidative stress (OE) that induces metabolic damage, hepatic IR and local inflammatory response, alterations similar to those observed in human MS. NAC (N-acetyl-cysteine) has antioxidant capacity, provides substrates for the synthesis of GSH and has a high absorption rate at liver. Objectives: to study the effects of the administration of NAC (orally and i.p.) at different doses, on endocrine-metabolic alterations induced by a fructose rich diet.

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