Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors

Aims Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by SR Ca...

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Detalles Bibliográficos
Autores principales:	Valverde, Carlos Alfredo, Mazzocchi, Gabriela, Di Carlo, Mariano Nahuel, Ciocci Pardo, Alejandro, Salas, Nehuén, Ragone, María Inés, Felice, Juan Ignacio, Cely Ortiz, Diana Catalina Alejandra, Consolini, Alicia Elvira, Portiansky, Enrique Leo, Mosca, Susana María, Kranias, Evangelia G., Wehrens, Xander H. T., Mattiazzi, Alicia Ramona
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2018
Materias:	Ciencias Médicas Arrhythmias CaMKII Calcium Calcium waves Phospholamban
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/124352
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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