Ivermectin repurposing for COVID-19 therapy: Safety and pharmacokinetic assessment of a novel nasal spray formulation in a pig model

High ivermectin (IVM) concentrations suppress in vitro SARS-CoV-2 replication. Nasal IVM spray (N-IVM-spray) administration may contribute to attaining high drug concentrations in nasopharyngeal (NP) tissue, a primary site of virus entrance/replication. The safety and pharmacokinetic performance of...

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Detalles Bibliográficos
Autores principales: Errecalde, Jorge Oscar, Lifschitz, Adrian Luis, Vecchioli, Graciela Isabel, Ceballos, Laura, Errecalde, Francisco, Ballent, Mariana, Marín, Gustavo Horacio, Daniele, Martín Rafael, Turic, Esteban, Spitzer, Eduardo, Toneguzzo, Fernando, Gold, Silvia, Krolewiecki, Alejandro J., Alvarez, Luis, Lanusse, Carlos Edmundo
Formato: Articulo Preprint
Lenguaje:Español
Publicado: 2020
Materias:
Ciencias Médicas
Pharmacokinetics
Adverse effect
Oral administration
Ivermectin
Respiratory tract
Nostril
Nasal spray
Medicine
Nasal administration
Pharmacology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124172
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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