Effect of epinephrine on the oxidative desaturation of fatty acids in the rat
The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-l...
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| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
1976
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/123448 |
| Aporte de: |
| Sumario: | The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal prepara- tions of rats has been studied. Administration of epi- nephrine (1 mg/kg body weight) produced a significant decrease in desaturation of ( 1-14C)linoleic acid to y- linolenic acid and of ( 1 -14C)cr-linolenic acid to octadeca- 6,9,12,15-tetraenoic acid 12 hr after the injection. Lower doses produced a lesser effect on the A6-desaturation activity. Epinephrine administration modified the V,,, of linoleic acid desaturation but not the K,. There was also a slight increase in palmityl desaturation activity. The ef- fect of epinephrine on A6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit A6-desaturation activity. |
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