The inhibition of voltage-gated H⁺ channel (HVCN1) induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis
Cellular energetic deregulation is widely known to produce an overproduction of acidic species in cancer cells. This acid overload must be counterbalanced with a high rate of H⁺ extrusion to maintain cell viability. In this sense, many H⁺ transporters have been reported to be crucial for cell surviv...
Guardado en:
| Autores principales: | Asuaje, Agustín, Smaldini, Paola Lorena, Martín, Pedro, Enrique, Nicolás Jorge, Orlowski, Alejandro, Aiello, Ernesto Alejandro, Gonzalez León, Carlos, Docena, Guillermo Horacio, Milesi, Verónica |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/109083 https://link.springer.com/article/10.1007%2Fs00424-016-1928-0 |
| Aporte de: |
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