Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes

In cardiac muscle, signaling through cAMP governs many fundamental cellular functions, including contractility, relaxation and automatism. cAMP cascade leads to the activation of the classic protein kinase A but also to the stimulation of the recently discovered exchange protein directly activated b...

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Autores principales: Lezcano, Noelia, Mariángelo, Juan Ignacio Elio, Vittone, Leticia, Wehrens, X. H. T., Said, María Matilde, Mundiña-Weilenmann, Cecilia
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
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Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107425
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5801154&blobtype=pdf
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