Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility

Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a...

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Detalles Bibliográficos
Autores principales: Mattiazzi, Alicia Ramona, Mundiña-Weilenmann, Cecilia, Vittone, Leticia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Médicas
Phospholamban
Cardiac relaxation
Contractility
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104650
http://hdl.handle.net/11336/61840
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.

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