Identification of cisapride as new inhibitor of putrescine uptake in Trypanosoma cruzi by combined ligand- and structure-based virtual screening
Nowadays, the pharmacological therapy for the treatment of Chagas disease is based on two old drugs, benznidazole and nifurtimox, which have restricted efficacy against the chronic phase of the illness. To overcome the lack of efficacy of the traditional drugs (and their considerable toxicity), new...
Guardado en:
| Autores principales: | Dietrich, Roque Carlos, Alberca, Lucas Nicolás, Ruiz, María Daniela, Palestro, Pablo Hernán, Carrillo, Carolina, Talevi, Alan, Gavernet, Luciana |
|---|---|
| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/101758 https://ri.conicet.gov.ar/11336/94472 |
| Aporte de: |
Ejemplares similares
-
Búsqueda asistida por computadora de nuevos fármacos antichagásicos análogos de poliaminas
por: Alberca, Lucas Nicolás
Publicado: (2018) -
Cascade ligand- and structure-based virtual screening to identify new trypanocidal compounds inhibiting putrescine uptake
por: Alberca, Lucas Nicolás, et al.
Publicado: (2018) -
2 D QSAR and docking of novel N-substitutedAryl amine derivatives as potential inhibitors of lumazine synthase
por: Bhatia, Manish S., et al.
Publicado: (2010) -
Dinámica y estática de vórtices en superconductores de alta temperatura crítica con defectos correlacionados /
Publicado: (2000) -
Estabilidad y formación de la fase superconductora 2223 del sistema (Bi,Pb)-Sr-Ca-Cu-O /
Publicado: (1994)