Synthesis, characterization and crystal structure of 2-chloroethyl(methylsulfonyl)methanesulfonate
The aim of this study was to evaluate the structural and vibrational properties and biological activity of 2-chloroethyl(methylsulfonyl)methanesulfonate, CH<sub>3</sub>SO<sub>2</sub>CH<sub>2</sub>SO<sub></sub>2OCH<sub>2</sub>CH<sub>2&...
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| Autores principales: | , , , , , , , , |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/100589 https://ri.conicet.gov.ar/11336/91281 https://pubs.rsc.org/en/content/articlelanding/2018/NJ/C7NJ05138G |
| Aporte de: |
| Sumario: | The aim of this study was to evaluate the structural and vibrational properties and biological activity of 2-chloroethyl(methylsulfonyl)methanesulfonate, CH<sub>3</sub>SO<sub>2</sub>CH<sub>2</sub>SO<sub></sub>2OCH<sub>2</sub>CH<sub>2</sub>Cl (clomesone). The solid-state molecular structure has been isolated and characterized using experimental (X-ray diffraction) and theoretical (DFT method) methodologies. The molecules are packed through C-H⋯O bifurcated interactions and Cl⋯Cl interactions. The experimental investigations are supplemented by quantum chemical calculations and Hirshfeld surface calculations. Furthermore, the infrared and Raman spectra of the solid phase have been obtained, and the observed bands are assigned to the vibrational normal modes. This study is completed using the atoms-in-molecules (AIM) theory and natural bond orbital (NBO) analysis. Finally, we studied the function of clomesone in biofilm formation and investigated a methanesulfonate complex with respect to QS activity. |
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