Bone ‘mechanostat’, directionality, and ancestral genes
All mobile bones auto-control their structural stiffness (and hence their ultimate strength) thanks to a feedback mechanism which operates at the cellular and tissue levels of complexity, known as ‘bone mechanostat’. This system was proposed by HM Frost as adapted to maintaining a ´safety factor’ of...
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| Lenguaje: | Español |
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Universidad Nacional de Rosario
2022
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| Acceso en línea: | https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/58 |
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I15-R235-article-582023-11-08T14:27:54Z Bone ‘mechanostat’, directionality, and ancestral genes Mecanostato’ óseo, direccionalidad, y genes ancestrales Cointry, Gustavo Roberto Biomecánica ósea Estructura ósea Competitividad Evolución Peroné Mecanostato óseo Bone biomechanics Bone structure Competitivity Evolution Fibula Bone mechanostat All mobile bones auto-control their structural stiffness (and hence their ultimate strength) thanks to a feedback mechanism which operates at the cellular and tissue levels of complexity, known as ‘bone mechanostat’. This system was proposed by HM Frost as adapted to maintaining a ´safety factor’ of about 6-10 concerning fracture risk with respect to the reaction of bone structure to maximal physiological efforts. Recent studies suggest that the scope of the alluded regulatory function of bone mechanostat could be enhanced, including the control of other bone structural properties which are more related to survival (i.e. ´selectively positive’) than to fracture risk. The new idea points out the importance of directionality concerning the therapeutic mechanical stimulation of bones. The available criteria to propose the above idea are exposed, supported by our as well as others’ arguments. Los huesos móviles autocontrolan su rigidez estructural (y con ella su resistencia a la fractura) por un servomecanismo que actúa a niveles celular y tisular de complejidad, llamado ‘mecanostato’ óseo. El sistema fue concebido por HM Frost como adaptado al mantenimiento de un ‘factor de seguridad’ de entre 6 y 10 respecto del riesgo de la producción de fracturas, en relación con la reacción estructural ósea a esfuerzos fisiológicos máximos. Estudios recientes sugieren que esta aptitud regulatoria del mecanostato óseos se podría ampliar, comprendiendo también el control de otras propiedades estructurales óseas, más relacionadas con la supervivencia (‘selectivamente positivas’) que con el riesgo de fracturas. La nueva concepción jerarquiza la direccionalidad de la estimulación mecánica terapéutica sobre la estructura ósea. Se exponen los criterios que avalan esta proposición, con argumentos propios y ajenos. Universidad Nacional de Rosario 2022-07-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/58 10.35305/fcm.v2i.58 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 2 (2021); 8-14 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/58/55 Derechos de autor 2022 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario. https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-235 |
| container_title_str |
FCM Científica |
| language |
Español |
| format |
Artículo revista |
| topic |
Biomecánica ósea Estructura ósea Competitividad Evolución Peroné Mecanostato óseo Bone biomechanics Bone structure Competitivity Evolution Fibula Bone mechanostat |
| spellingShingle |
Biomecánica ósea Estructura ósea Competitividad Evolución Peroné Mecanostato óseo Bone biomechanics Bone structure Competitivity Evolution Fibula Bone mechanostat Cointry, Gustavo Roberto Bone ‘mechanostat’, directionality, and ancestral genes |
| topic_facet |
Biomecánica ósea Estructura ósea Competitividad Evolución Peroné Mecanostato óseo Bone biomechanics Bone structure Competitivity Evolution Fibula Bone mechanostat |
| author |
Cointry, Gustavo Roberto |
| author_facet |
Cointry, Gustavo Roberto |
| author_sort |
Cointry, Gustavo Roberto |
| title |
Bone ‘mechanostat’, directionality, and ancestral genes |
| title_short |
Bone ‘mechanostat’, directionality, and ancestral genes |
| title_full |
Bone ‘mechanostat’, directionality, and ancestral genes |
| title_fullStr |
Bone ‘mechanostat’, directionality, and ancestral genes |
| title_full_unstemmed |
Bone ‘mechanostat’, directionality, and ancestral genes |
| title_sort |
bone ‘mechanostat’, directionality, and ancestral genes |
| description |
All mobile bones auto-control their structural stiffness (and hence their ultimate strength) thanks to a feedback mechanism which operates at the cellular and tissue levels of complexity, known as ‘bone mechanostat’. This system was proposed by HM Frost as adapted to maintaining a ´safety factor’ of about 6-10 concerning fracture risk with respect to the reaction of bone structure to maximal physiological efforts. Recent studies suggest that the scope of the alluded regulatory function of bone mechanostat could be enhanced, including the control of other bone structural properties which are more related to survival (i.e. ´selectively positive’) than to fracture risk. The new idea points out the importance of directionality concerning the therapeutic mechanical stimulation of bones. The available criteria to propose the above idea are exposed, supported by our as well as others’ arguments. |
| publisher |
Universidad Nacional de Rosario |
| publishDate |
2022 |
| url |
https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/58 |
| work_keys_str_mv |
AT cointrygustavoroberto bonemechanostatdirectionalityandancestralgenes AT cointrygustavoroberto mecanostatooseodireccionalidadygenesancestrales |
| first_indexed |
2023-06-26T22:51:02Z |
| last_indexed |
2024-08-12T21:45:35Z |
| _version_ |
1807219829853126656 |