Gut barrier function. Implication in celiac disease.
The intestinal mucosa is the largest and most dynamic immune environment of the body. It is the first site of exposure to pathogens, but at the same time it is constantly exposed to harmless environmental antigens, food particles and commensal microflora that need to be tolerated. Therefore, the mai...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional de Rosario
2021
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| Acceso en línea: | https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/16 |
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I15-R235-article-162023-11-08T14:27:33Z Gut barrier function. Implication in celiac disease. Función de la barrera intestinal. Implicancia en la enfermedad celíaca. Villanueva, Silvina Stella Maris Perdomo, Virginia Gabriela García, Fabiana Sistema inmune Intestino Enfermedad celíaca Immune system Intestine Celiac Disease The intestinal mucosa is the largest and most dynamic immune environment of the body. It is the first site of exposure to pathogens, but at the same time it is constantly exposed to harmless environmental antigens, food particles and commensal microflora that need to be tolerated. Therefore, the main functions of the mucosal immune system are the induction of tolerance (or non—reaction) against innocuous antigens and commensal bacteria as well as the development of an immune response against pathogens. In this context, hypersensitivity responses against antigens in the diet can lead to inflammatory disorders such as celiac disease. Therefore the aim of this review is to provide an overview of the recent literature on the maintenance of homeostasis in the intestinal mucosa and the disease state that can ensue when this balance is lost. En la mucosa intestinal se encuentra el mayor y más dinámico entorno inmunológico del cuerpo. Es el primer sitio de exposición a patógenos, pero al mismo tiempo está constantemente expuesta a antígenos ambientales inocuos, partículas de alimentos y microflora comensal que necesitan ser tolerados. Por lo tanto las funciones principales del sistema inmune de las mucosas son la inducción de tolerancia (o no reacción) frente a antígenos inocuos y bacterias comensales así como el desarrollo de una respuesta inmune contra los patógenos. En este contexto las respuestas de hipersensibilidad contra los antígenos de la dieta pueden conducir a trastornos inflamatorios como la enfermedad celíaca. Por lo tanto el objetivo de esta revisión es proporcionar una descripción general de la literatura reciente sobre el mantenimiento de la homeostasis en la mucosa intestinal y del estado de enfermedad que puede sobrevenir cuando se pierde este equilibrio. Universidad Nacional de Rosario 2021-07-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/16 10.35305/fcm.v1i.16 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 1 (2020); 9-22 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/16/33 https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Universidad Nacional de Rosario |
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I-15 |
| repository_str |
R-235 |
| container_title_str |
FCM Científica |
| language |
Español |
| format |
Artículo revista |
| topic |
Sistema inmune Intestino Enfermedad celíaca Immune system Intestine Celiac Disease |
| spellingShingle |
Sistema inmune Intestino Enfermedad celíaca Immune system Intestine Celiac Disease Villanueva, Silvina Stella Maris Perdomo, Virginia Gabriela García, Fabiana Gut barrier function. Implication in celiac disease. |
| topic_facet |
Sistema inmune Intestino Enfermedad celíaca Immune system Intestine Celiac Disease |
| author |
Villanueva, Silvina Stella Maris Perdomo, Virginia Gabriela García, Fabiana |
| author_facet |
Villanueva, Silvina Stella Maris Perdomo, Virginia Gabriela García, Fabiana |
| author_sort |
Villanueva, Silvina Stella Maris |
| title |
Gut barrier function. Implication in celiac disease. |
| title_short |
Gut barrier function. Implication in celiac disease. |
| title_full |
Gut barrier function. Implication in celiac disease. |
| title_fullStr |
Gut barrier function. Implication in celiac disease. |
| title_full_unstemmed |
Gut barrier function. Implication in celiac disease. |
| title_sort |
gut barrier function. implication in celiac disease. |
| description |
The intestinal mucosa is the largest and most dynamic immune environment of the body. It is the first site of exposure to pathogens, but at the same time it is constantly exposed to harmless environmental antigens, food particles and commensal microflora that need to be tolerated. Therefore, the main functions of the mucosal immune system are the induction of tolerance (or non—reaction) against innocuous antigens and commensal bacteria as well as the development of an immune response against pathogens. In this context, hypersensitivity responses against antigens in the diet can lead to inflammatory disorders such as celiac disease. Therefore the aim of this review is to provide an overview of the recent literature on the maintenance of homeostasis in the intestinal mucosa and the disease state that can ensue when this balance is lost. |
| publisher |
Universidad Nacional de Rosario |
| publishDate |
2021 |
| url |
https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/16 |
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2023-06-26T22:50:54Z |
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2024-08-12T21:45:28Z |
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