Annexin A2 and S100A10 in the mammalian oviduct
In many mammals, upon entry into the female reproductive tract, a subpopulation of sperm is stored in the oviduct forming a functional reservoir. In the oviducts of pig and cow, Annexin A2 (AnxA2) has been linked to the binding of sperm. This protein may exist as a monomer or bound to S100A10 a...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Springer-Verlag
2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/9344 http://hdl.handle.net/2133/9344 |
| Aporte de: |
| id |
I15-R121-2133-9344 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Anexina S100A10 Trompas de Falopio Reservorio de espermatozoides Oviducto |
| spellingShingle |
Anexina S100A10 Trompas de Falopio Reservorio de espermatozoides Oviducto Teijeiro, Juan Manuel Roldán, María Lorena Marini, Patricia Estela Annexin A2 and S100A10 in the mammalian oviduct |
| topic_facet |
Anexina S100A10 Trompas de Falopio Reservorio de espermatozoides Oviducto |
| description |
In many mammals, upon entry into the female reproductive
tract, a subpopulation of sperm is stored in the
oviduct forming a functional reservoir. In the oviducts of pig
and cow, Annexin A2 (AnxA2) has been linked to the binding
of sperm. This protein may exist as a monomer or bound to
S100A10 and both forms are associated with different biological
functions. S100A10 has not yet been reported in the oviduct.
The objective of this work is to analyze for the presence
of S100A10 in the oviduct and to advance the study of AnxA2
and S100A10 in this organ. This work shows the presence of
both proteins, AnxA2 and S100A10, in the oviduct of human,
pig, cow, cat, dog and rabbit. At least in pig, AnxA2 is found
devoid of S100A10 in the outer surface of the apical plasma
membrane of oviductal epithelial cells, indicating that it binds
to sperm as a monomer or in association with proteins different
from S100A10. In the apical cytoplasm of pig oviductal
epithelial cells, AnxA2 is associated with S100A10. In primary
culture of porcine oviductal cells, the expression of ANXA2
is increased by progesterone, while the expression of S100A10
is increased by progesterone and estradiol. The widespread
detection of both proteins in the oviduct of mammals indicates
a probable conserved function in this organ. In summary,
S100A10 and AnxA2 are widespread in the mammalian
oviduct but AnxA2 binds sperm in vivo devoid of S100A10
and may be related to reservoir formation. |
| format |
article artículo publishedVersion |
| author |
Teijeiro, Juan Manuel Roldán, María Lorena Marini, Patricia Estela |
| author_facet |
Teijeiro, Juan Manuel Roldán, María Lorena Marini, Patricia Estela |
| author_sort |
Teijeiro, Juan Manuel |
| title |
Annexin A2 and S100A10 in the mammalian oviduct |
| title_short |
Annexin A2 and S100A10 in the mammalian oviduct |
| title_full |
Annexin A2 and S100A10 in the mammalian oviduct |
| title_fullStr |
Annexin A2 and S100A10 in the mammalian oviduct |
| title_full_unstemmed |
Annexin A2 and S100A10 in the mammalian oviduct |
| title_sort |
annexin a2 and s100a10 in the mammalian oviduct |
| publisher |
Springer-Verlag |
| publishDate |
2017 |
| url |
http://hdl.handle.net/2133/9344 http://hdl.handle.net/2133/9344 |
| work_keys_str_mv |
AT teijeirojuanmanuel annexina2ands100a10inthemammalianoviduct AT roldanmarialorena annexina2ands100a10inthemammalianoviduct AT marinipatriciaestela annexina2ands100a10inthemammalianoviduct |
| bdutipo_str |
Repositorios |
| _version_ |
1764820413850845188 |