Immobilized boronic acid for Suzuki–Miyaura coupling: application to the generation of pharmacologically relevant molecules
An synthetic strategy for the generation of a variety of biaryl and related derivatives, based on Suzuki– Miyaura coupling using immobilized boronic acid, is described. The importance of the methodology was demonstrated by its further application to biologically interesting compounds such as 4-bia...
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| Autores principales: | , , |
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| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/19545 http://hdl.handle.net/2133/19545 |
| Aporte de: |
| Sumario: | An synthetic strategy for the generation of a variety of biaryl and related derivatives, based on Suzuki–
Miyaura coupling using immobilized boronic acid, is described. The importance of the methodology was
demonstrated by its further application to biologically interesting compounds such as 4-biaryl-blactams, descripted as cholesterol absorption inhibitors and anti-MRSA active agents, neoflavonoids,
imidazoles, isoxazolines, among others. |
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