Repositioning Salirasib as a new antimalarial agent

Malaria is a serious tropical disease that kills thousands of people every year, mainly in Africa, due to Plasmodium falciparum infections. Salirasib is a promising cancer drug candidate that interferes with the post-translational modification of Ras. This S-farnesyl thiosalicylate inhibits isopreny...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Porta, Exequiel Oscar Jesús, Bofill Verdaguer, Ignasi, Perez, Consuelo, Banchio, Claudia, Ferreira de Azevedo, Mauro, Katzin, Alejandro M., Labadie, Guillermo Roberto
Formato:	article artículo acceptedVersion
Lenguaje:	Inglés
Publicado:	Royal Society of Chemistry 2020
Materias:	Malaria Drug repurposing Click Chemistry Plasmodium falciparum Salirasib Thiosalicylates
Acceso en línea:	http://hdl.handle.net/2133/18278 http://hdl.handle.net/2133/18278
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

Ejemplares similares

More on protein glycosylation in the malaria parasite (multiple letters) [1]
por: Kimura, E.A., et al.

Characterization of the isoprenoid chain of coenzyme Q in Plasmodium falciparum
por: De Macedo, C.S., et al.

More on protein glycosylation in the malaria parasite (multiple letters) [1]
por: Couto, Alicia Susana
Publicado: (2000)

Characterization of the isoprenoid chain of coenzyme Q in Plasmodium falciparum
Publicado: (2002)

Antimalarial activity of new acridinone derivatives
por: Fernández-Calienes, A., et al.

Antimalarial activity of new acridinone derivatives
por: Fascio, Mirta Liliana, et al.
Publicado: (2011)

Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
por: Simão-Gurge, Raquel M., et al.
Publicado: (2020)

In <i>silico</i> Guided Drug Repurposing : Discovery of New Competitive and Non-competitive Inhibitors of Falcipain-2
por: Alberca, Lucas Nicolás, et al.
Publicado: (2019)

Glicómica : la espectrometría de masa UV-Maldi-Tof como herramienta en la determinación de la vía biosintética de esfingolípidos de hemoparásitos
por: Landoni, Malena
Publicado: (2010)

Glicómica : la espectrometría de masa UV-Maldi-Tof como herramienta en la determinación de la vía biosintética de esfingolípidos de hemoparásitos
por: Landoni, Malena
Publicado: (2010)

Glicómica : la espectrometría de masa UV-Maldi-Tof como herramienta en la determinación de la vía biosintética de esfingolípidos de hemoparásitos
por: Landoni, Malena
Publicado: (2010)

Plasmodium falciparum biosynthesizes sulfoglycosphingolipids
por: Landoni, M., et al.

Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets
por: Bélgamo, Julián Alberto, et al.
Publicado: (2020)

Plasmodium falciparum biosynthesizes sulfoglycosphingolipids
por: Landoni, Malena, et al.
Publicado: (2007)

Antimalarial activity of new acridinone derivatives
por: Fernández-Calienes, A.
Publicado: (2011)

Glycosphingolipids in Plasmodium falciparum: Presence of an active glucosylceramide synthase
por: Couto, A.S., et al.

Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum
por: Goulart, H.R., et al.

Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: Presence of dolichols of 11 and 12 isoprene units
por: Couto, A.S., et al.

Glycosphingolipids in Plasmodium falciparum: Presence of an active glucosylceramide synthase
Publicado: (2004)

Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum
Publicado: (2004)

Metabolic oligosaccharide engineering of Plasmodium falciparum intraerythrocytic stages allows direct glycolipid analysis by mass spectrometry
por: Piñero, T., et al.

Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: Presence of dolichols of 11 and 12 isoprene units
Publicado: (1999)

Metabolic oligosaccharide engineering of Plasmodium falciparum intraerythrocytic stages allows direct glycolipid analysis by mass spectrometry
Publicado: (2012)

N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum
por: Kimura, E.A., et al.
Publicado: (1996)

N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum
por: Kimura, E.A., et al.

N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum
por: Kimura, E.A., et al.
Publicado: (1996)

Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum
por: Piñero, T.A., et al.

Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity
por: Van Baren, C., et al.

Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity
Publicado: (2006)

N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum
por: Couto, Alicia Susana, et al.
Publicado: (1996)

Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum
Publicado: (2018)

A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases
por: Berenstein, A.J., et al.

A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases
Publicado: (2016)

Modelling potential malaria spread in Germany by use of climate change projections a risk assessment approach coupling epidemiologic and geostatistical measures
por: Schröder, Winfried
Publicado: (2014)

Modelling potential malaria spread in Germany by use of climate change projections a risk assessment approach coupling epidemiologic and geostatistical measures
por: Schröder, Winfried
Publicado: (2014)

Endogenous galectin-3 controls experimental malaria in a species-specific manner
por: Toscano, M.A., et al.

Endogenous galectin-3 controls experimental malaria in a species-specific manner
por: Toscano, Marta Alicia
Publicado: (2012)

Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health
por: Newton, P.N., et al.

Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: Selecting for drug-resistant malaria and threatening public health
Publicado: (2008)

Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan
por: Bouche, Gauthier, et al.
Publicado: (2018)