Physiological concentrations of unconjugated bilirubin prevent oxidative stress-induced hepatocanalicular dysfunction and cholestasis

Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most hepatopathies, induces cholestasis by actin cytoskeleton disarrangement and f...

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Autores principales: Basiglio, Cecilia Lorena, Toledo, Flavia D., Boaglio, Andrea C., Arriaga, Sandra Mónica María, Ochoa, Justina E., Sánchez Pozzi, Enrique Juan, Mottino, Aldo D., Roma, Marcelo Gabriel
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Springer 2018
Materias:
Unconjugated Bilirubin
Oxidative Stress
Hepatocellular Cholestasis
Canalicular Transporters
Acceso en línea:http://hdl.handle.net/2133/10482
http://hdl.handle.net/2133/10482
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

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