Efecto del tamoxifen sobre la glandula sublingual y submaxilar de la rata
This study \vas performed to determine the histomorphological effectsof tamoxifen (a nonsteroid antioestrocren) in rat sumaxillary and sublingualglands.Forty vVistar rats, young adults, males and females, were used in thestudy. The animals were divided. in the follow:ing groups: 1) Normal control2)...
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| Autores principales: | , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Facultad de Odontología
2019
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/25904 |
| Aporte de: |
| Sumario: | This study \vas performed to determine the histomorphological effectsof tamoxifen (a nonsteroid antioestrocren) in rat sumaxillary and sublingualglands.Forty vVistar rats, young adults, males and females, were used in thestudy. The animals were divided. in the follow:ing groups: 1) Normal control2) Castrated 15 days 'befare the beginning of the study, 3) Inyectedwitb tamoxifen durir!g 15 days, 4) Castrated and injected with tamoxifenduring 15 days. .The animals were killed \vith an overdose of ether, and submaxillaryand sublingual glmids were removed .A morphological study of salivary glands was performed, using sectionsstained with H. E. The histochernical reactions used were: PAS, AB pH 1 and2.5, both in combination \vith P AS.The sublingml glands of the anin1als receiving tamoxifen lost SeJ,."U::lldimOr[lhism, the parenchyma became very compact, but lhis characteristicwas nor obwrved when castrated. Castration didn't increas.;: or decrease thedrug's effect over either sex. ·In submaxillary glands tamoxifen changed their sexual dirnosphism andthe adni secretion, affected males and females bnt when they were exposedboth to t11e drug and castration, females showed more intense differences Íl•the achlis ( accord:ng to lustometric results) .Conclusions tamoxifen has an evideut effect en sublingual and submaxiUaryglands. It is suggested then, that this could result from the possibkpresence of specific estrogen receptors in these glands, which wold be blockedby tamoxifen. |
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