7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital
Congenital Adrenal Hyperplasia (CAH) is a group of steroidogenesis disorders caused by enzymatic defects in the pathway of glucocorticoid and/or mineralocorticoid synthesis. It is characterized by cortisol deficiency, androgen excess, and occasionally aldosterone deficiency with salt loss. This...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2025
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/50349 |
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I10-R327-article-50349 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
neonatal screening congenital adrenal hyperplasia prematurity 17-Hydroxyprogesterone pesquisa neonatal hiperplasia suprarrenal congénita prematuridad 17-Hidroxiprogesterona . |
| spellingShingle |
neonatal screening congenital adrenal hyperplasia prematurity 17-Hydroxyprogesterone pesquisa neonatal hiperplasia suprarrenal congénita prematuridad 17-Hidroxiprogesterona . Olmos Vera, JM Marioni, FA Carranza Calvimonte, PO Medina, AG Saura, A Pereira, MI Gonzalez, A Sembaj, A 7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital |
| topic_facet |
neonatal screening congenital adrenal hyperplasia prematurity 17-Hydroxyprogesterone pesquisa neonatal hiperplasia suprarrenal congénita prematuridad 17-Hidroxiprogesterona . |
| author |
Olmos Vera, JM Marioni, FA Carranza Calvimonte, PO Medina, AG Saura, A Pereira, MI Gonzalez, A Sembaj, A |
| author_facet |
Olmos Vera, JM Marioni, FA Carranza Calvimonte, PO Medina, AG Saura, A Pereira, MI Gonzalez, A Sembaj, A |
| author_sort |
Olmos Vera, JM |
| title |
7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital |
| title_short |
7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital |
| title_full |
7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital |
| title_fullStr |
7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital |
| title_full_unstemmed |
7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital |
| title_sort |
7-hydroxyprogesterone values in healthy preterm newborns screened at the maternity and neonatology university hospital |
| description |
Congenital Adrenal Hyperplasia (CAH) is a group of steroidogenesis disorders caused by enzymatic defects in the pathway of glucocorticoid and/or mineralocorticoid synthesis. It is characterized by cortisol deficiency, androgen excess, and occasionally aldosterone deficiency with salt loss. This condition is included in neonatal screening, reducing morbidity and mortality in newborns (NB). 17α-hydroxyprogesterone (17-OHP), the biochemical marker for diagnosis and follow-up of patients with CAH, is influenced by gestational age (GA), chronological age (CA), sex, birth weight (BW), stress, illness, and interfering steroids. Therefore, a second measurement should be performed at 15 days of life. The objective was to describe 17-OHP values adjusted for BW in preterm newborns (PTNB), to compare values obtained in the first and second sample collection, and to assess their association with maternal history.
Samples from PTNB screened for CAH between 08/04/2023 and 07/17/2024 at CEPIDEM, Maternity and Neonatology University Hospital, were analyzed. This retrospective cross-sectional study included 42 PTNB divided into two groups: G1: 23 PTNB, BW ≤ 2500g, and G2: 16 PTNB, BW > 2500g. Determination of 17-OHP in dried blood spots was performed by ELISA at birth (1stS) and at 15 days of life (2ndS). The cutoff value for 17-OHP in term newborns (TN) is <30 ng/mL.
The 17-OHP values (ng/mL) were: G1, 1stS 25.8 ± 18.1 and 2ndS 16.9 ± 4.5; G2, 1stS 16.6 ± 5.5 and 2ndS 14.3 ± 2.8, showing significant differences in both groups (p<0.001). 17-OHP values were higher in PTNB compared to TN, with greater elevations in G1. A decrease in 17-OHP values was observed at 2ndS in both groups. Maternal history revealed increased substance abuse, which could contribute to prematurity.
Study limitations included the small number of NB per group and incomplete medical records. Adjusting 17-OHP values for BW is useful to improve diagnostic specificity, reduce false positives, and decrease the rate of recalls for the 2ndS.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2025 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/50349 |
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I10-R327-article-503492025-11-13T12:04:31Z 7-Hydroxyprogesterone values in healthy preterm newborns screened at the Maternity and Neonatology University Hospital Valores de 17-hidroxiprogesterona en recién nacidos sanos pretérmino tamizados en el Hospital Universitario de Maternidad y Neonatología . Olmos Vera, JM Marioni, FA Carranza Calvimonte, PO Medina, AG Saura, A Pereira, MI Gonzalez, A Sembaj, A neonatal screening congenital adrenal hyperplasia prematurity 17-Hydroxyprogesterone pesquisa neonatal hiperplasia suprarrenal congénita prematuridad 17-Hidroxiprogesterona . Congenital Adrenal Hyperplasia (CAH) is a group of steroidogenesis disorders caused by enzymatic defects in the pathway of glucocorticoid and/or mineralocorticoid synthesis. It is characterized by cortisol deficiency, androgen excess, and occasionally aldosterone deficiency with salt loss. This condition is included in neonatal screening, reducing morbidity and mortality in newborns (NB). 17α-hydroxyprogesterone (17-OHP), the biochemical marker for diagnosis and follow-up of patients with CAH, is influenced by gestational age (GA), chronological age (CA), sex, birth weight (BW), stress, illness, and interfering steroids. Therefore, a second measurement should be performed at 15 days of life. The objective was to describe 17-OHP values adjusted for BW in preterm newborns (PTNB), to compare values obtained in the first and second sample collection, and to assess their association with maternal history. Samples from PTNB screened for CAH between 08/04/2023 and 07/17/2024 at CEPIDEM, Maternity and Neonatology University Hospital, were analyzed. This retrospective cross-sectional study included 42 PTNB divided into two groups: G1: 23 PTNB, BW ≤ 2500g, and G2: 16 PTNB, BW > 2500g. Determination of 17-OHP in dried blood spots was performed by ELISA at birth (1stS) and at 15 days of life (2ndS). The cutoff value for 17-OHP in term newborns (TN) is <30 ng/mL. The 17-OHP values (ng/mL) were: G1, 1stS 25.8 ± 18.1 and 2ndS 16.9 ± 4.5; G2, 1stS 16.6 ± 5.5 and 2ndS 14.3 ± 2.8, showing significant differences in both groups (p<0.001). 17-OHP values were higher in PTNB compared to TN, with greater elevations in G1. A decrease in 17-OHP values was observed at 2ndS in both groups. Maternal history revealed increased substance abuse, which could contribute to prematurity. Study limitations included the small number of NB per group and incomplete medical records. Adjusting 17-OHP values for BW is useful to improve diagnostic specificity, reduce false positives, and decrease the rate of recalls for the 2ndS. La Hiperplasia Suprarrenal Congénita (HSC) es un grupo de trastornos de la esteroidogénesis causada por defectos enzimáticos en la vía de la síntesis de los glucocorticoides y/o mineralocorticoides. Presentan deficiencia de cortisol, exceso de andrógenos, ocasionalmente con deficiencia de aldosterona y pérdida salina. Esta patología está incluida en la pesquisa neonatal reduciendo la morbimortalidad de recién nacidos (RN). La 17α hidroxiprogesterona (17-OHP), marcador bioquímico para diagnóstico y seguimiento de pacientes con HSC, está influenciada por: edad gestacional (EG), edad cronológica (EC), sexo, peso al nacer (PN), estrés, enfermedad e interferentes esteroideos, por ello debe realizarse un segundo dosaje a los 15 días de nacido. El objetivo fue describir los valores de 17-OHP ajustados al PN en RN pre-término (RNPT), comparar los valores obtenidos en la primera y segunda toma de muestra y asociarlos con antecedentes maternos. Para ello se utilizaron muestras de RNPT pesquisados para HSC del 04/08/2023 al 17/07/2024 en el CEPIDEM, Hospital Universitario de Maternidad y Neonatología. En este trabajo, de corte transversal retrospectivo, se incluyeron 42 RNPT divididos en dos grupos: G1: 23 RNPT, PN ≤ 2500g y G2: 16 RNPT, PN > 2500g. La determinación de 17-OHP en sangre seca se realizó por ELISA, al nacer (1raM) y a los 15 días de nacido (2daM). El valor de corte para la 17-OHP de RN a término (RNT) es < a 30 ng/ml. Los valores para 17-OHP (ng/ml) fueron: G1, 1raM 25,8 ± 18,1 y 2daM 16,9 ± 4,5 y G2 1raM 16,6 ± 5,5 y 2daM 14,3 ± 2,8 mostrando ambos grupos diferencias significativas p<0,001. Los valores de 17-OHP resultaron elevados en RNPT en comparación con RNT, siendo mayor en el G1. Se evidencia un descenso de los valores de 17OHP en la 2daM en los grupos. Los antecedentes maternos mostraron incremento del consumo de drogas de abuso, que podrían determinar la prematuridad del RN. Las limitaciones del estudio fueron bajo número de RN por grupo y no contar con HC completas. Resulta útil ajustar los valores de 17-OHP al PN para mejorar la especificidad diagnóstica, disminuir falsos positivos y la tasa de recitaciones para 2daM . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025-11-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/50349 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 82 (2025): Suplemento JIC XXVI Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 82 (2025): Suplemento JIC XXVI Revista da Faculdade de Ciências Médicas de Córdoba; v. 82 (2025): Suplemento JIC XXVI 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/50349/50523 Derechos de autor 2025 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |