Detection of Human Polyomavirus (HPyV) in Cervical Samples from Women with and without Lesions in Córdoba, Argentina, and its Co-Infection with Human Papillomavirus (HPV)
Human polyomaviruses (HPyV) and papillomaviruses (HPV) include oncogenic viruses. Studies have demonstrated a link between the development of cervical neoplasia and HPV; however, only a fraction of HPV-positive women develop cancer. It has been proposed that an interaction between HPV/HPyV could inc...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/46578 |
| Aporte de: |
| Sumario: | Human polyomaviruses (HPyV) and papillomaviruses (HPV) include oncogenic viruses. Studies have demonstrated a link between the development of cervical neoplasia and HPV; however, only a fraction of HPV-positive women develop cancer. It has been proposed that an interaction between HPV/HPyV could increase the risk of cervical neoplasia. Due to the lack of studies in our country, we aimed to determine HPyV infection in cervical samples from women with and without lesions in Córdoba, as well as co-infection with HPV.
A total of 143 DNA samples from cervical swabs (CS) were studied, with 65 samples corresponding to women with lesions (WL) of high and low grades, and 78 samples from women without lesions (WWL). The samples were analyzed by PCR for HPyV T antigen and revealed by agarose gel electrophoresis.
20% (13/65) of WL tested positive for HPyV, with a mean age of 31 years (range: 19-55 years). Among the HPyV-positive samples, 84% (11/13) had low-grade lesions, and 16% (2/13) had high-grade lesions. HPyV/HPV co-infection (genotypes 6, 11, 16, and 45) was found in 30.8% (4/13) of the HPyV-positive samples. Among the HPyV-positive women, 53.8% (7/13) used oral contraceptives (OCs), had no pregnancies or deliveries, and 15.4% (2/13) had experienced abortions. In the WWL group, 25.6% (20/78) tested positive for HPyV, with a mean age of 28.6 years (range: 18-38 years), and 5% (1/20) presented co-infection with HPV (genotype 18). Among these women, 60% (12/20) used OCs, and 70% (14/20) had no pregnancies, deliveries, or abortions.
This is the first report of HPyV in cervical samples in Argentina. The high prevalence of HPyV in the cervix indicates the need for further studies to determine the clinical implications of this finding. This is especially important for the group of women with lesions, where a high percentage of co-infection with both viruses was found. This study provides a foundation for future research that could improve prevention and management strategies for cervical viral infections, contributing to the health of the female population in Córdoba. |
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