Coronavirus: eco-epidemiology of the endemic strain HCoV-OC43, in children hospitalized at the Municipal Children's Hospital of the City of Córdoba
HCoV-OC43 causes frequent acute upper and lower respiratory tract infections, causing global morbidity and mortality in children under 4 years of age. We determined the circulation, clinical picture and seasonality of HCoV-OC43 in monoinfection and coinfection along with o...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Artículo revista |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/39136 |
| Aporte de: |
| Sumario: | HCoV-OC43 causes frequent acute upper and lower respiratory tract infections, causing global morbidity and mortality in children under 4 years of age. We determined the circulation, clinical picture and seasonality of HCoV-OC43 in monoinfection and coinfection along with other respiroviruses already detected by the Municipal Children's Hospital (HIM-Córdoba) in hospitalized patients aged 1m-14years with lower ARI, during 2018-2019.
This is an observational, descriptive, cross-sectional, annual study in 1,053 samples, focusing on HCoV-OC43. HIM detected by direct immunofluorescence (DIF) respiratory panel as epidemiological context to determine HCoV-OC43 by RT-PCR. The prevalence of respiratory infections of confirmed etiology was described by percentages expressed in tables, bar, line and pie charts applying Microsoft Excel-2013 functions. The seasonal distribution of HCoV-OC43 was organized by month in relation to other respiroviruses and to climatic variable data obtainedfrom OMIXOM software.
The overall prevalence of all respiroviruses was 77.86% (820/1053), with a prevalence of 5.41% (57/1053) for HCoV-OC43, including monoinfections (27/57) and coinfections (30/57) with hRSV and hMPV with prevalences of 22% (13/57) and 3.5% (2/57) respectively. Treatment was symptomatic, avoiding the use of antibiotics in monoinfections and viral coinfections, which was very well received and applied by pediatricians. It predominated in patients up to 2 years of age, male, generating Bronchial Obstructive Syndrome, Bronchiolitis, Asthma, Pneumonia and other ARI. The seasonality of HCoV-OC43 presented the characteristic behavior of respiroviruses, although there were numerous cases of summer monoinfection, whose significant prevalence was: 31.6% (18/57) being novel, behavior similar to that of tropical countries.
This research, a valuable contribution to the health of the pediatric community, broadened the knowledge of HCoV-OC43, very little studied in Córdoba. It demonstrated the circulation, clinical and seasonality of HCoV-OC43 in monoinfection and coinfection with other respiroviruses in infants. Molecular detection of HCoV-OC43 added to routine differential diagnosis by IFD is a remarkable and effective expanded strategy in initial screening. Endemic epidemiologic surveillance was activated to alert for epidemic emergencies. Appropriate treatment was optimized, providing public health strategies and preventive measures, improving health conditions in the country. |
|---|