Detección del virus Papiloma Humano en lesiones cancerosas orales en la ciudad de Córdoba
Oral cancer is a process thai involves diffurent etiological factors and meehanisms in the light of current view of viral cocarcinogenesis Evidenee from histology and DNA hybridization studies suggests that l-lPV is ingaged in oral carcinogenesis. The Pathology Laboratory of the Dentistry School, Na...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2023
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/38734 |
| Aporte de: |
| Sumario: | Oral cancer is a process thai involves diffurent etiological factors and meehanisms in the light of current view of viral cocarcinogenesis Evidenee from histology and DNA hybridization studies suggests that l-lPV is ingaged in oral carcinogenesis. The Pathology Laboratory of the Dentistry School, National University of Córdoba, admits approximately 20% of aH patients svith cancerous lesions in this city.In the January 1 992-December 1997 lapse, ve examined 1950 biopsies with oral lesions, 4.77% (93/1950 ) of which sere malignant neoplasnis. 79.571,1 /,, (74/93) were oral carcinomas. Thirty-three oral Carcinomas (44.6%; 33/74) were selcctcd at randoni andincluded in this study. 33 eells smears of normal oral mucosa of controls individuals were included. Thcy were analyzed by conventional [ight niicroSCOpy and an in situ hybridization technique for the detection o) HPV. Data were analyzed \vith chi square test. The prevalence of HPV among the 33 cancer samplcs studied vas 9/33 tested positive for l-IPV in low stringent conditions.Only one was positive in high stringent coiidi ion for 1-1 PV 16, a verrugous carcinoma. No HPV-DNA was detected in celis smcars ofcontrols. Aniong the I-IF'V positive, 3/9 (33 .33%)were squamous carcinomas and 5/9 (55.56%) were verrugous carcinomas. Onlyune vas a rrielanoma. Verrugous carcinoma vas the carcinoma most associated with the HPV inlection (x2 =20.5; 95% leve¡ ofconlidence). This would indicate a major role of FIPV in the pathogencsis of verrucous carcinomas. The viral prevalence found incancerous lesions reintbrces the concepi o)' 1ictcrogenic natures of oral cancer. HPV is a circumstancc tliat increase the probability of rnalignancy, and whcn reducing, diminish the frequency of cancer. |
|---|