Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma

Guidelines suggest a thyrotropin (TSH) stimulation level ≥30 mIU/l for the administration of 131-iodine (I131) in patients with differentiated thyroid carcinoma (DTC). We present a patient with follicular thyroid carcinoma (FTC), with spinal metastasis as the initial manifestation, who after 6 weeks...

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Autores principales: Ramírez Stieben, Luis Agustín, Queralt, Mariana, Sylvestre Begnis, Gustavo, Polillo, David, Barrenechea, Ignacio
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023
Materias:
thyroid neoplasms
thyrotropine
iodine
neoplasias de la tiroides
tirotropina
yodo
neoplasias da glândula tireoide
tireotropina
iodo
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/38112
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-38112
record_format ojs
spelling I10-R327-article-381122023-08-01T15:45:15Z Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma Elevación insuficiente de TSH antes de la terapia con I131 en paciente con carcinoma diferenciado de tiroides metastásico Elevação insuficiente de TSH antes da terapia com I131 em paciente com carcinoma diferenciado de tireoide metastático Ramírez Stieben, Luis Agustín Queralt, Mariana Sylvestre Begnis, Gustavo Polillo, David Barrenechea, Ignacio thyroid neoplasms thyrotropine iodine neoplasias de la tiroides tirotropina yodo neoplasias da glândula tireoide tireotropina iodo Guidelines suggest a thyrotropin (TSH) stimulation level ≥30 mIU/l for the administration of 131-iodine (I131) in patients with differentiated thyroid carcinoma (DTC). We present a patient with follicular thyroid carcinoma (FTC), with spinal metastasis as the initial manifestation, who after 6 weeks without levothyroxine did not present an elevation of ≥30 mIU/l of TSH. This situation was interpreted as secondary to the presence of functioning metastases and it was decided, regardless of the TSH level, to administer a therapeutic dose of I131, with iodine-uptake lesions in the liver and spine being confirmed. Las guías sugieren un nivel de estimulación de tirotrofina (TSH) ≥30 mUI/l para la administración de yodo 131 (I131) en pacientes con carcinoma diferenciado de tiroides (CDT). Presentamos una paciente con carcinoma folicular de tiroides (CFT), con metástasis vertebral como manifestación inicial, que tras 6 semanas sin levotiroxina no presentó una elevación ≥30 mUI/l de TSH. Esta situación fue interpretada como secundaria a la presencia de metástasis funcionantes y se decidió, independientemente del valor de TSH, la administración de una dosis terapéutica de I131 constatándose lesiones captantes de I131 en hígado y columna vertebral. As diretrizes sugerem um nível de estimulação de tireotropina (TSH) ≥30 mUI/l para a administração de iodo 131 (I131) em pacientes com carcinoma diferenciado de tireoide (CDT). Apresentamos um paciente com carcinoma folicular da tireoide (CFT), com metástase vertebral como manifestação inicial, que após 6 semanas sem levotiroxina não apresentou elevação ≥30 mUI/l de TSH. Esta situação foi interpretada como secundária à presença de metástases funcionantes e decidiu-se, independentemente do valor de TSH, administrar uma dose terapêutica de 131I, confirmando as lesões de captação de 131I no fígado e na coluna. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Text Texto Texto text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/38112 10.31053/1853.0605.v80.n2.38112 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 No. 2 (2023); 149-152 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 Núm. 2 (2023); 149-152 Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 n. 2 (2023); 149-152 1853-0605 0014-6722 10.31053/1853.0605.v80.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/38112/42250 https://revistas.unc.edu.ar/index.php/med/article/view/38112/41754 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic thyroid neoplasms
thyrotropine
iodine
neoplasias de la tiroides
tirotropina
yodo
neoplasias da glândula tireoide
tireotropina
iodo
spellingShingle thyroid neoplasms
thyrotropine
iodine
neoplasias de la tiroides
tirotropina
yodo
neoplasias da glândula tireoide
tireotropina
iodo
Ramírez Stieben, Luis Agustín
Queralt, Mariana
Sylvestre Begnis, Gustavo
Polillo, David
Barrenechea, Ignacio
Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma
topic_facet thyroid neoplasms
thyrotropine
iodine
neoplasias de la tiroides
tirotropina
yodo
neoplasias da glândula tireoide
tireotropina
iodo
author Ramírez Stieben, Luis Agustín
Queralt, Mariana
Sylvestre Begnis, Gustavo
Polillo, David
Barrenechea, Ignacio
author_facet Ramírez Stieben, Luis Agustín
Queralt, Mariana
Sylvestre Begnis, Gustavo
Polillo, David
Barrenechea, Ignacio
author_sort Ramírez Stieben, Luis Agustín
title Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma
title_short Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma
title_full Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma
title_fullStr Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma
title_full_unstemmed Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma
title_sort insufficient elevation of tsh before therapy with i131 in a patient with metastatic differentiated thyroid carcinoma
description Guidelines suggest a thyrotropin (TSH) stimulation level ≥30 mIU/l for the administration of 131-iodine (I131) in patients with differentiated thyroid carcinoma (DTC). We present a patient with follicular thyroid carcinoma (FTC), with spinal metastasis as the initial manifestation, who after 6 weeks without levothyroxine did not present an elevation of ≥30 mIU/l of TSH. This situation was interpreted as secondary to the presence of functioning metastases and it was decided, regardless of the TSH level, to administer a therapeutic dose of I131, with iodine-uptake lesions in the liver and spine being confirmed.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2023
url https://revistas.unc.edu.ar/index.php/med/article/view/38112
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first_indexed 2024-09-03T21:03:38Z
last_indexed 2024-09-03T21:03:38Z
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