Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent
Abstract: Summary: The causes of clitoromegaly can be hormonal and non-hormonal. Among the hormonal ones, endocrinopathies, virilizing tumors and of the adrenal gland are described. Among the non-hormonal benign tumors of the clitoris including fibromas, leiomyomas, angiokeratomas, pseudol...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35017 |
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I10-R327-article-35017 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
Key Words clitoromegaly, etiology histopathology inclusion cysts clitoromegalia etiología histopatología quistes de inclusión |
| spellingShingle |
Key Words clitoromegaly, etiology histopathology inclusion cysts clitoromegalia etiología histopatología quistes de inclusión Sotelo , A Bongiorni C , C Trezza , C Asis , G Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| topic_facet |
Key Words clitoromegaly, etiology histopathology inclusion cysts clitoromegalia etiología histopatología quistes de inclusión |
| author |
Sotelo , A Bongiorni C , C Trezza , C Asis , G |
| author_facet |
Sotelo , A Bongiorni C , C Trezza , C Asis , G |
| author_sort |
Sotelo , A |
| title |
Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| title_short |
Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| title_full |
Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| title_fullStr |
Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| title_full_unstemmed |
Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| title_sort |
presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent |
| description |
Abstract:
Summary:
The causes of clitoromegaly can be hormonal and non-hormonal. Among the hormonal ones, endocrinopathies, virilizing tumors and of the adrenal gland are described. Among the non-hormonal benign tumors of the clitoris including fibromas, leiomyomas, angiokeratomas, pseudolymphomas, hemangiomas, glandular cell tumors, hemangiopercytomas and neurofibromas are described. There are cases of both epithelial and mesenchymal malignant tumors. Cysts of the female genital tract are extremely rare, and even more so are those of the clitoris. Some cases of epidermoid cysts of the clitoris, both congenital and acquired, have been reported in the literature. Epidermoid cysts of the clitoris are generally secondary to trauma. The communication of this case tries to highlight the importance of arriving at the etiology of this clinical-pathological entity, which will guide the adequate treatment of this pathology. 16-year-old female patient, reason for consultation with increased size of the clitoris for a year. He denies a history of trauma. Take oral contraceptives. Gynecological examination: menarche at 10 years of age, a significant increase in the clitoris without hypertrophy of the labia minora is found on physical examination. Imaging result corresponding to soft tissue ultrasound: superficial cystic image in projection of the clitoris, measures 34x12x20 mm. The wall is 0.3mm. Surgical treatment and subsequent pathological study of the lesion are indicated for the patient. In the Laboratory, the material is processed with the usual techniques and colored with H&E
Macroscopy: fragmented cystic formation is received (4 fragments) measuring 2.5 cm in diameter grouped together. When cut, the internal surface is smooth, without content. Rough and grayish external surface, elastic consistency. Microscopy: the sections show the cyst wall lined by stratified flat epithelium with mild hyper and parakeratosis, it exhibits signs suggestive of HPV (koilocytosis). The stroma is fibrohyaline with congestive blood vessels. Diagnosis: findings linked to epidermal inclusion cyst, clitoral hypertrophy, and signs suggestive of HPV viral infection. The clinical-pathological case presented highlights the importance of both clinical and imaging aspects as well as the histopathological diagnosis of this entity, which were strongly associated with the etiology of clitoromegaly |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35017 |
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I10-R327-article-350172024-04-15T16:19:09Z Presentation of a clinical- pathological case of clitomegaly in a 16- year- old adolescent Presentación de un caso clínico - patológico clitoromegalia en adolescente de 16 años Sotelo , A Bongiorni C , C Trezza , C Asis , G Key Words clitoromegaly, etiology histopathology inclusion cysts clitoromegalia etiología histopatología quistes de inclusión Abstract: Summary: The causes of clitoromegaly can be hormonal and non-hormonal. Among the hormonal ones, endocrinopathies, virilizing tumors and of the adrenal gland are described. Among the non-hormonal benign tumors of the clitoris including fibromas, leiomyomas, angiokeratomas, pseudolymphomas, hemangiomas, glandular cell tumors, hemangiopercytomas and neurofibromas are described. There are cases of both epithelial and mesenchymal malignant tumors. Cysts of the female genital tract are extremely rare, and even more so are those of the clitoris. Some cases of epidermoid cysts of the clitoris, both congenital and acquired, have been reported in the literature. Epidermoid cysts of the clitoris are generally secondary to trauma. The communication of this case tries to highlight the importance of arriving at the etiology of this clinical-pathological entity, which will guide the adequate treatment of this pathology. 16-year-old female patient, reason for consultation with increased size of the clitoris for a year. He denies a history of trauma. Take oral contraceptives. Gynecological examination: menarche at 10 years of age, a significant increase in the clitoris without hypertrophy of the labia minora is found on physical examination. Imaging result corresponding to soft tissue ultrasound: superficial cystic image in projection of the clitoris, measures 34x12x20 mm. The wall is 0.3mm. Surgical treatment and subsequent pathological study of the lesion are indicated for the patient. In the Laboratory, the material is processed with the usual techniques and colored with H&E Macroscopy: fragmented cystic formation is received (4 fragments) measuring 2.5 cm in diameter grouped together. When cut, the internal surface is smooth, without content. Rough and grayish external surface, elastic consistency. Microscopy: the sections show the cyst wall lined by stratified flat epithelium with mild hyper and parakeratosis, it exhibits signs suggestive of HPV (koilocytosis). The stroma is fibrohyaline with congestive blood vessels. Diagnosis: findings linked to epidermal inclusion cyst, clitoral hypertrophy, and signs suggestive of HPV viral infection. The clinical-pathological case presented highlights the importance of both clinical and imaging aspects as well as the histopathological diagnosis of this entity, which were strongly associated with the etiology of clitoromegaly Resumen: Las causas de clitoromegalia pueden ser hormonales y no hormonales. Entre las hormonales se describen endocrinopatías, tumores virilizantes y de la glándula adrenal. Entre las no hormonales se describen tumores benignos del clítoris que incluyen fibromas, leiomiomas, angioqueratomas, pseudolinfomas, hemangiomas, tumores de células glandulares, hemangiopercitomas y neurofibromas. Hay casos de tumores malignos tanto epiteliales como mesenquimales. Los quistes del tracto genital femenino son extremadamente raros y aún más los del clítoris. Se han reportado en la literatura algunos casos de quistes epidermoides de clítoris, tanto de tipo congénito como adquiridos. Los quistes epidermoides de clítoris generalmente son secundarios a trauma. La comunicación de este caso intenta resaltar la importancia de arribar a la etiología de esta entidad clínico-patológica, la cual orientará al tratamiento adecuado de esta patología. Paciente sexo femenino de 16 años de edad, motivo de consulta aumento de tamaño del clítoris desde hace un año. Niega antecedentes de traumatismo. Toma anticonceptivos orales. Examen ginecológico: menarca a los 10 años, se constata al examen físico aumento significativo del clítoris sin hipertrofia de labios menores. Resultado imagenológico correspondiente a ecografía de partes blandas: imagen quística superficial en proyección del clítoris, mide 34x12x20 mm. La pared es de 0,3mm. Se indica a la paciente tratamiento quirurgico y posterior estudio anatomopatológico de la lesion. En el Laboratorio se procesa el material con las técnicas habituales y se colorea con H&E Macroscopía: se recibe formación quística fragmentada (4 fragmentos) miden agrupados 2,5 cm de diámetro. Al corte la superficie interna es lisa, sin contenido. Superficie externa rugosa y grisácea, consistencia elástica. Microscopía: los cortes muestran pared de quiste revestida por epitelio plano estratificado con leve hiper y paraqueratosis, el mismo exhibe signos sugestivos de VPH (coilocitosis). El estroma es fibrohialino con vasos sanguíneos congestivos. Diagnóstico: hallazgos vinculables con quiste de inclusión epidérmico, hipertrofia de clítoris y signos sugestivos de infección viral por VPH. El caso clínico-patológico presentado resalta la importancia de los aspectos tanto clínicos como imagenológicos así como del diagnóstico histopatológico de esta entidad, los cuales estuvieron fuertemente asociados con la etiología de la clitoromegalia Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35017 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |