Overexpression of the Her-1 oncogene and its relationship with histopathological prognostic variables in invasive cervical cancer
Abstract: Cervical cancer is the leading cause of death in women of reproductive age in developing countries. The treatment of advanced stages is frequently unsatisfactory. Overexpression of the epidermal growth factor receptor (EGFR or Her1) could play a significant role in signaling both...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35009 |
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| Sumario: | Abstract:
Cervical cancer is the leading cause of death in women of reproductive age in developing countries. The treatment of advanced stages is frequently unsatisfactory. Overexpression of the epidermal growth factor receptor (EGFR or Her1) could play a significant role in signaling both tumor genesis and growth. It’s not clearly defined yet its clinical and therapeutic utility or whether it constitutes a predictor of poor prognosis. Therefore, it is of interest to investigate new histoprognostic factors associated with its overexpression.
Retrospective Cohort Study. Samples of tumor tissues were studied from thirty patients who attended the Hospital Nacional de Clínicas, and nine from the Sanatorio Allende, both in Córdoba city. The diagnosis was invasive cervical cancer (2 adenocarcinomas, 1 adenosquamous and 36 squamous cell carcinomas) treated with radical Wertheim Meiggs hysterectomy or radical abdominal trachelectomy. EGFR pharmDx ™ Kit for EGFR (HER1) diagnostic assay was used to determine the overexpression of HER1 on tumoral tissue. Total absence of staining was considered a negative result. Any intensity of cell membrane staining was considered positive, with increasing values from +1 to +3. The relationship with the following variables was analyzed: mitotic count and nuclear grade, vasculolymphatic invasion and presence of lymph node metastases. Student's t test was used for comparison of data. A p-value < 0.05 was considered statistically significant.
Her1 overexpression was associated with tumors with a high mitotic count and presence of poorly differentiated cells on microscopic examination (G3) (p=0.047). There was no significant relationship with vasculolymphatic invasion or the existence of lymph node metastases.
Her1 overexpression seems to be related to histopathological variables of poor prognosis that are related to the cellular kinetics of the primary tumor. The lack of a consistent relationship with lymph node metastases and vasculolymphatic invasion could be explained by underlying mechanisms other than Her1-mediated signaling. The determination of Her1 overexpression could constitute a valid tool to help choose among different therapeutic strategies: adjuvant chemotherapy, postoperative radiotherapy and / or concurrent chemotherapy. |
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