Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report
Abstract: Carcinoma of unknown primary origin represents 3-5% of malignant tumours in adult patients, and is defined as the presence of an advanced carcinoma (with lymph node/distant metastases) with no evidence of a primary origin even after carrying out exhaustive diagnostic techniques....
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35006 |
| Aporte de: |
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I10-R327-article-35006 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
squamous cell carcinoma unknown primary neoplasms lymphatic metastasis carcinoma de células escamosas neoplasias primarias desconocidas metástasis linfática |
| spellingShingle |
squamous cell carcinoma unknown primary neoplasms lymphatic metastasis carcinoma de células escamosas neoplasias primarias desconocidas metástasis linfática Perez , C Masciarelli , L Aguado, G Ferraris , L Storniolo , A Gonzalez , C Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| topic_facet |
squamous cell carcinoma unknown primary neoplasms lymphatic metastasis carcinoma de células escamosas neoplasias primarias desconocidas metástasis linfática |
| author |
Perez , C Masciarelli , L Aguado, G Ferraris , L Storniolo , A Gonzalez , C |
| author_facet |
Perez , C Masciarelli , L Aguado, G Ferraris , L Storniolo , A Gonzalez , C |
| author_sort |
Perez , C |
| title |
Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| title_short |
Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| title_full |
Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| title_fullStr |
Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| title_full_unstemmed |
Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| title_sort |
cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report |
| description |
Abstract:
Carcinoma of unknown primary origin represents 3-5% of malignant tumours in adult patients, and is defined as the presence of an advanced carcinoma (with lymph node/distant metastases) with no evidence of a primary origin even after carrying out exhaustive diagnostic techniques. The histologic type that most frequently affects cervical lymph nodes is the squamous cell carcinoma, which usually presents as the metastasis or infiltration from a clinically occult oropharyngeal carcinoma, generally human papillomavirus (HPV)-positive, in which case they tend to have a better prognosis than their HPV-negative counterpart.
The objective of this presentation is to report the case of a cervical lymph node metastasis from squamous cell carcinoma that originated in the head and neck region, with no possible way of determining the specific location due to the lesion's clinical characteristics.
A 66-year old male patient with no known medical history consulted for trismus, weight loss and a left laterocervical mass over the prior 2 months. An ultrasound revealed multiple laterocervical lymphadenopathies. A fine needle aspiration was then performed, with the diagnosis of carcinoma. The diagnostic tests subsequently effectuated were unable to ascertain the lesion's possible primary origin. Thereupon, the lymph node conglomerate was excised and its examination exhibited a squamous cell neoplasm with positive p16 immunostaining.
According to recommendations of the College of American Pathologists in 2018, the confirmation of p16 reactivity in cases of cervical lymph node metastases from squamous cell carcinoma of unknown primary origin would aid in the distinction of an oropharyngeal primary tumour, as well as its association with the human papillomavirus, which carries prognostic value. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35006 |
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2024-09-03T21:02:55Z |
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I10-R327-article-350062024-04-15T16:19:09Z Cervical lymph node metastasis from squamous cell carcinoma of unknown primary origin: a case report Metástasis en ganglio linfático cervical de carcinoma escamoso oculto: presentación de un caso Perez , C Masciarelli , L Aguado, G Ferraris , L Storniolo , A Gonzalez , C squamous cell carcinoma unknown primary neoplasms lymphatic metastasis carcinoma de células escamosas neoplasias primarias desconocidas metástasis linfática Abstract: Carcinoma of unknown primary origin represents 3-5% of malignant tumours in adult patients, and is defined as the presence of an advanced carcinoma (with lymph node/distant metastases) with no evidence of a primary origin even after carrying out exhaustive diagnostic techniques. The histologic type that most frequently affects cervical lymph nodes is the squamous cell carcinoma, which usually presents as the metastasis or infiltration from a clinically occult oropharyngeal carcinoma, generally human papillomavirus (HPV)-positive, in which case they tend to have a better prognosis than their HPV-negative counterpart. The objective of this presentation is to report the case of a cervical lymph node metastasis from squamous cell carcinoma that originated in the head and neck region, with no possible way of determining the specific location due to the lesion's clinical characteristics. A 66-year old male patient with no known medical history consulted for trismus, weight loss and a left laterocervical mass over the prior 2 months. An ultrasound revealed multiple laterocervical lymphadenopathies. A fine needle aspiration was then performed, with the diagnosis of carcinoma. The diagnostic tests subsequently effectuated were unable to ascertain the lesion's possible primary origin. Thereupon, the lymph node conglomerate was excised and its examination exhibited a squamous cell neoplasm with positive p16 immunostaining. According to recommendations of the College of American Pathologists in 2018, the confirmation of p16 reactivity in cases of cervical lymph node metastases from squamous cell carcinoma of unknown primary origin would aid in the distinction of an oropharyngeal primary tumour, as well as its association with the human papillomavirus, which carries prognostic value. El carcinoma de origen primario desconocido corresponde a un 3-5% de las neoplasias malignas en el adulto y se define como la presencia de carcinoma en estadio avanzado (con metástasis ganglionares o a distancia) sin evidencia de lesión primaria tras la realización de estudios diagnósticos exhaustivos. A nivel cervical el tipo histológico más frecuente es el carcinoma epidermoide y éste a su vez suele representar la metástasis o infiltración de un carcinoma orofaríngeo clínicamente oculto, en general positivo para HPV, siendo éste de mejor pronóstico. El objetivo de esta presentación es reportar un caso de metástasis linfática cervical de carcinoma escamoso con localización primaria en cabeza y cuello e imposibilidad de determinar el sitio específico de orígen debido a las características clínicas de la lesión. Se trata de un paciente de sexo masculino, de 66 años, sin otros antecedentes patológicos conocidos, que consultó por trismus, pérdida de peso y tumoración laterocervical izquierda de 2 meses de evolución. Por medio de una ecografía se observó la presencia de adenopatías laterocervicales. Se realizó una punción aspiración con aguja fina, arribándose al diagnóstico de carcinoma. Los estudios llevados a cabo con posterioridad, no objetivaron el posible origen primario de la lesión. Se procedió a la exéresis de conglomerado ganglionar en el que se observó la presencia de una neoplasia de células escamosas, que resultó positiva para la inmunomarcación con p16. Según lo sugerido por el Colegio Americano de Patólogos en el año 2018, la confirmación por inmunohistoquímica de positividad para p16 en metástasis cervicales de carcinoma de células escamosas de orígen desconocido, aproximaría al orígen orofaríngeo del tumor primario, como así también su relación con el virus de HPV, lo cual tiene un importante valor pronóstico. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35006 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |