Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy
Abstract: Disseminated intravascular coagulation (DIC) occurs as a complication of a wide variety of disorders. COVID-19 may predispose tromboembolic disease due to excessive inflammation, hypoxia and immobilisation. The coagulation function in patients with SARS-CoV-2 is significantly der...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/34967 |
| Aporte de: |
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I10-R327-article-34967 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
Disseminated Intravascular Coagulation COVID-19 Coagulación Intravascular Diseminada COVID-19 |
| spellingShingle |
Disseminated Intravascular Coagulation COVID-19 Coagulación Intravascular Diseminada COVID-19 Storniolo Squintone , A Roman , P Paredes , E De Uriarte , F Dib , D Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy |
| topic_facet |
Disseminated Intravascular Coagulation COVID-19 Coagulación Intravascular Diseminada COVID-19 |
| author |
Storniolo Squintone , A Roman , P Paredes , E De Uriarte , F Dib , D |
| author_facet |
Storniolo Squintone , A Roman , P Paredes , E De Uriarte , F Dib , D |
| author_sort |
Storniolo Squintone , A |
| title |
Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy |
| title_short |
Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy |
| title_full |
Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy |
| title_fullStr |
Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy |
| title_full_unstemmed |
Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy |
| title_sort |
diffuse intravascular coagulation associated with covid-19: histopathological findings in autopsy |
| description |
Abstract:
Disseminated intravascular coagulation (DIC) occurs as a complication of a wide variety of disorders. COVID-19 may predispose tromboembolic disease due to excessive inflammation, hypoxia and immobilisation. The coagulation function in patients with SARS-CoV-2 is significantly deranged compared with healthy people. But due to the fact that thrombotic complications have not been analyzed collectively and compared to other viruses, there is not yet a safe conclusion as to whether SARS-CoV-2 is responsible for a worse rate of thrombotic manifestations, compared to other respiratory viruses, or not.
We present the histopathological findings of a rare case, in order to document and report DIC as a cause of death in patients with COVID-19 even in young patients without comorbidities. The case corresponds to an 18-year-old woman, without basic diseases, diagnosed with bilateral pneumonia due to COVID-19 who after hospital discharge presents gastrointestinal symptoms and dies at home. Autopsy is performed at the IMF and referred to the forensic pathology service for histopathological study of the brain, cerebellum, heart, lungs, liver, spleen and kidney. The processing of the materials was carried out by routine techniques and colored with hematoxylin-eosin. On macroscopic examination the organs showed congestive. Microscopic examination exhibits the presence of microthrombos in the arterioles and capillaries of the lungs, kidney and heart. The importance of the case lies in communicating and learning more about thrombotic complications in COVID-19 patients, which are of utmost importance for considering thromboprophylaxis. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/34967 |
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I10-R327-article-349672024-04-15T16:19:09Z Diffuse intravascular coagulation associated with COVID-19: histopathological findings in autopsy Coagulación intravascular diseminada asociada a COVID-19: hallazgos histopatológicos de autopsia Storniolo Squintone , A Roman , P Paredes , E De Uriarte , F Dib , D Disseminated Intravascular Coagulation COVID-19 Coagulación Intravascular Diseminada COVID-19 Abstract: Disseminated intravascular coagulation (DIC) occurs as a complication of a wide variety of disorders. COVID-19 may predispose tromboembolic disease due to excessive inflammation, hypoxia and immobilisation. The coagulation function in patients with SARS-CoV-2 is significantly deranged compared with healthy people. But due to the fact that thrombotic complications have not been analyzed collectively and compared to other viruses, there is not yet a safe conclusion as to whether SARS-CoV-2 is responsible for a worse rate of thrombotic manifestations, compared to other respiratory viruses, or not. We present the histopathological findings of a rare case, in order to document and report DIC as a cause of death in patients with COVID-19 even in young patients without comorbidities. The case corresponds to an 18-year-old woman, without basic diseases, diagnosed with bilateral pneumonia due to COVID-19 who after hospital discharge presents gastrointestinal symptoms and dies at home. Autopsy is performed at the IMF and referred to the forensic pathology service for histopathological study of the brain, cerebellum, heart, lungs, liver, spleen and kidney. The processing of the materials was carried out by routine techniques and colored with hematoxylin-eosin. On macroscopic examination the organs showed congestive. Microscopic examination exhibits the presence of microthrombos in the arterioles and capillaries of the lungs, kidney and heart. The importance of the case lies in communicating and learning more about thrombotic complications in COVID-19 patients, which are of utmost importance for considering thromboprophylaxis. Resumen: La coagulación intravascular diseminada (CID) se produce como complicación de una amplia variedad de trastornos. El COVID-19 puede predisponer a enfermedad tromboembólica debido a la excesiva inflamación, hipoxia e inmovilización. Se sabe que la función de la coagulación en pacientes con SARS-CoV-2 está marcadamente alterada comparada con personas sanas. Pero debido al hecho de que las complicaciones trombóticas no se han analizado colectivamente y en comparación con otros virus, no existe aún una conclusión segura sobre si el SARS-CoV-2 es responsable de una peor tasa de manifestaciones trombóticas, en comparación con otros virus respiratorios, o no. Se presentan los hallazgos histopatológicos de un caso poco comun, con el objeto de documentar y comunicar como causa de muerte la CID en pacientes con COVID-19 aun en pacientes jovenes y sin comorbilidades. El caso corresponde a una mujer de 18 años, sin enfermedades de base, con diagnóstico de neumonía bilateral por COVID-19 que posterior al alta hospitalaria presenta síntomas gastrointestinales y fallece en su domicilio. Se realiza autopsia en el IMF y se remiten al servicio de Patología Forense para estudio histopatológico cerebro, cerebelo, corazón, pulmones, hígado, bazo y riñón. El procesamiento de los materiales fue realizado por técnicas de rutina y coloreados con hematoxilina-eosina. Al examen macroscópico presenta órganos de aspecto congestivo. En el examen microscópico se evidencia la presencia de microtrombos en las arteriolas y en los capilares de los pulmones, riñón y corazón. La importancia del caso radica en comunicar y conocer más sobre las complicaciones trombóticas en pacientes COVID-19, de suma importancia para considerar la tromboprofilaxis. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/34967 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |