Spiroadenoma with partial cystic degeneration: presentation of a case
Abstract: Spiroadenoma is a benign sweat gland neoplasm originally described by Kersting and Helwig. It generally appears in adults as a single, sometimes painful or tender nodule located on the head, neck or trunk. It is made up of one or more well-circumscribed lobes in the...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/34930 |
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I10-R327-article-34930 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
sweat glands lymphocytes blood vessels glándulas sudoríparas linfocitos vasos sanguíneos . |
| spellingShingle |
sweat glands lymphocytes blood vessels glándulas sudoríparas linfocitos vasos sanguíneos . Rivas, DA Defazio, ND Spiroadenoma with partial cystic degeneration: presentation of a case |
| topic_facet |
sweat glands lymphocytes blood vessels glándulas sudoríparas linfocitos vasos sanguíneos . |
| author |
Rivas, DA Defazio, ND |
| author_facet |
Rivas, DA Defazio, ND |
| author_sort |
Rivas, DA |
| title |
Spiroadenoma with partial cystic degeneration: presentation of a case |
| title_short |
Spiroadenoma with partial cystic degeneration: presentation of a case |
| title_full |
Spiroadenoma with partial cystic degeneration: presentation of a case |
| title_fullStr |
Spiroadenoma with partial cystic degeneration: presentation of a case |
| title_full_unstemmed |
Spiroadenoma with partial cystic degeneration: presentation of a case |
| title_sort |
spiroadenoma with partial cystic degeneration: presentation of a case |
| description |
Abstract:
Spiroadenoma is a benign sweat gland neoplasm originally described by Kersting and Helwig. It generally appears in adults as a single, sometimes painful or tender nodule located on the head, neck or trunk. It is made up of one or more well-circumscribed lobes in the dermis composed of a double epithelial population with focal ductal differentiation and intratumoral lymphocytes. It is accompanied by an edematous stroma with blood and lymphatic vessels. There are other forms of clinical presentation and histopathological variants of this tumor, including a cystic form.
A 50-year-old man consulted for a two-year evolution of a nodule on the left forearm. We received a 3 cm nodule referred as a "cystic lesion" covered by skin. On section it was solid with cystic areas containing bloody fluid. It was processed with routine techniques and stained with hematoxylin/eosin. Microscopy: well defined dermal proliferation of two types of epithelial cells without atypia arranged in cords and with ductal differentiation. Between both components there was a variable number of lymphocytes. The stroma was not very evident in the solid areas but in other sectors it was distended by abundant edema forming cavities with amorphous eosinophilic material, fibrin and red blood cells. Some cavities even showed signs of organization and old bleeding. The surgical boundary was free.
There are multiple clinical presentations and morphological variations of spiroadenoma. The cystic form can be explained by cystic distention of the perivascular spaces of the stroma, which are a typical feature of this tumor. They correspond to spaces of variable size around one or more blood vessels and are delimited by a palisade of tumor epithelial cells, findings similar to those seen in thymomas. They contain a variable number of lymphocytes and could participate in their transit to the tumor. They may also contain proteinaceous material or erythrocytes and form large cavities in the tumor which can manifest clinically as a cystic lesion similar to the case we present.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/34930 |
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AT rivasda spiroadenomawithpartialcysticdegenerationpresentationofacase AT defaziond spiroadenomawithpartialcysticdegenerationpresentationofacase AT rivasda espiroadenomacondegeneracionquisticaparcialpresentaciondeuncaso AT defaziond espiroadenomacondegeneracionquisticaparcialpresentaciondeuncaso AT rivasda a AT defaziond a |
| first_indexed |
2024-09-03T21:02:48Z |
| last_indexed |
2024-09-03T21:02:48Z |
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1809210271133073408 |
| spelling |
I10-R327-article-349302024-04-15T16:19:09Z Spiroadenoma with partial cystic degeneration: presentation of a case Espiroadenoma con degeneración quística parcial: presentación de un caso A Rivas, DA Defazio, ND sweat glands lymphocytes blood vessels glándulas sudoríparas linfocitos vasos sanguíneos . Abstract: Spiroadenoma is a benign sweat gland neoplasm originally described by Kersting and Helwig. It generally appears in adults as a single, sometimes painful or tender nodule located on the head, neck or trunk. It is made up of one or more well-circumscribed lobes in the dermis composed of a double epithelial population with focal ductal differentiation and intratumoral lymphocytes. It is accompanied by an edematous stroma with blood and lymphatic vessels. There are other forms of clinical presentation and histopathological variants of this tumor, including a cystic form. A 50-year-old man consulted for a two-year evolution of a nodule on the left forearm. We received a 3 cm nodule referred as a "cystic lesion" covered by skin. On section it was solid with cystic areas containing bloody fluid. It was processed with routine techniques and stained with hematoxylin/eosin. Microscopy: well defined dermal proliferation of two types of epithelial cells without atypia arranged in cords and with ductal differentiation. Between both components there was a variable number of lymphocytes. The stroma was not very evident in the solid areas but in other sectors it was distended by abundant edema forming cavities with amorphous eosinophilic material, fibrin and red blood cells. Some cavities even showed signs of organization and old bleeding. The surgical boundary was free. There are multiple clinical presentations and morphological variations of spiroadenoma. The cystic form can be explained by cystic distention of the perivascular spaces of the stroma, which are a typical feature of this tumor. They correspond to spaces of variable size around one or more blood vessels and are delimited by a palisade of tumor epithelial cells, findings similar to those seen in thymomas. They contain a variable number of lymphocytes and could participate in their transit to the tumor. They may also contain proteinaceous material or erythrocytes and form large cavities in the tumor which can manifest clinically as a cystic lesion similar to the case we present. Resumen: El espiroadenoma es una neoplasia benigna de glándulas sudoríparas descripta originalmente por Kersting y Helwig. Aparece en adultos generalmente como un nódulo único, a veces doloroso o sensible ubicado en cabeza, cuello o tronco. Está conformado por uno o más lóbulos bien circunscriptos en la dermis compuestos por una doble población epitelial con diferenciación ductal focal y linfocitos intratumorales. Se acompaña de una estroma edematosa con vasos sanguíneos y linfáticos. Existen otras formas de presentación clínica y variantes histo-patológicas de este tumor entre las cuales se halla una forma quística. Hombre de 50 años consultó por un nódulo en antebrazo izquierdo de dos años de evolución. Recibimos remitido como “lesión quística” un nódulo de 3 cm. de diámetro recubierto por piel. Al corte era sólido con áreas quísticas que contenían líquido sanguinolento. Se procesó con técnicas de rutina y se coloreó con hematoxilina/eosina. Microscopía: proliferación dérmica bien delimitada de dos tipos de células epiteliales sin atipia dispuestas en cordones y con diferenciación ductal. Entre ambos componentes había un número variable de linfocitos. La estroma era poco evidente en las áreas sólidas pero en otros sectores estaba distendida por abundante edema llegando a formar cavidades con material eosinófilo amorfo, fibrina y hematíes. Incluso algunas cavidades mostraban signos de organización y hemorragia antigua. El límite quirúrgico estaba libre. Existen múltiples presentaciones clínicas y variaciones morfológicas de espiroadenoma. La forma quística puede explicarse por la distensión quística de los espacios perivasculares de la estroma, que constituyen una característica típica de este tumor. Corresponden a espacios de tamaño variable alrededor de uno o varios vasos sanguíneos y están delimitados por una empalizada de células epiteliales tumorales, hallazgos similares a los que se observan en timomas. Contienen variable número de linfocitos y podrían participar en el tránsito de los mismos hacia el tumor. También pueden contener material proteináceo o eritrocitos y formar grandes cavidades en el tumor, lo cual puede manifestarse clínicamente como una lesión quística similar al caso que presentamos. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/34930 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |