Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital
Abstract: Intrahepatic Cholestasis of Pregnancy (ICD) is a pathology associated with serious adverse perinatal outcomes. They include: spontaneous preterm birth, asphyxia or fetal distress, meconium-stained amniotic fluid and intrauterine fetal death. Our objective was to establish ra...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/34919 |
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I10-R327-article-34919 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
Gestational Cholestasis Bile acids Pruritus Intrauterine fetal death Colestasis Gestacional Ácidos biliares Prurito Muerte fetal Intraútero . |
| spellingShingle |
Gestational Cholestasis Bile acids Pruritus Intrauterine fetal death Colestasis Gestacional Ácidos biliares Prurito Muerte fetal Intraútero . Crescente , SJC Lopez , AL Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| topic_facet |
Gestational Cholestasis Bile acids Pruritus Intrauterine fetal death Colestasis Gestacional Ácidos biliares Prurito Muerte fetal Intraútero . |
| author |
Crescente , SJC Lopez , AL |
| author_facet |
Crescente , SJC Lopez , AL |
| author_sort |
Crescente , SJC |
| title |
Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| title_short |
Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| title_full |
Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| title_fullStr |
Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| title_full_unstemmed |
Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| title_sort |
intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital |
| description |
Abstract:
Intrahepatic Cholestasis of Pregnancy (ICD) is a pathology associated with serious adverse perinatal outcomes. They include: spontaneous preterm birth, asphyxia or fetal distress, meconium-stained amniotic fluid and intrauterine fetal death.
Our objective was to establish rates of adverse perinatal outcomes according to serum bile acids concentrations, transaminases and bilirubin, in patients of the Obstetric Service of the Provincial Maternal Hospital during 2020.
Observational, retrospective, cross-sectional and descriptive study. Patients with a confirmed clinical and / or biochemical diagnosis of ICD were evaluated, who received follow-up and completed their pregnancy in the Obstetrics Service of the institution previously mentioned. These patients should have laboratories with serum bile acid concentrations, transaminases and bilirubins, for diagnosis, monitoring and at the time of termination of pregnancy.
38 patients with a diagnosis of ICD were included. An incidence of 1.1 out of 100 live new-borns was established. 44.73% presented low perinatal risk, 23.69% moderate risk, and 31.37% high risk, according to biochemical markers. 33.6% completed their pregnancy at 37 weeks, except for those who presented values> 40 micromol / L, even with treatment, which were completed between 32 and 6.6 weeks. Fetal and neonatal deaths were not recorded. The Apgar score at birth after a minute was of 8 +/- 1 standard deviation, and the Apgar score after 5 minutes was of 9 +/- 0.87 standard deviations. The mean weight of the newborn was 2880 grams. 73.1% did not present meconium-stained amniotic fluid. Spontaneous preterm birth occurred in 10.52% of cases.
The gestational age at the end of pregnancy is based on high serum bile acid concentrations, biochemical markers most important, together with serum levels of transaminases, to determine the severity of the pathology, monitor and define the termination of pregnancy.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/34919 |
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I10-R327-article-349192024-04-15T16:19:09Z Intrahepatic cholestasis of pregnancy: relationship among serum bile acid concentrations, transaminases and bilirubin with adverse perinatal outcomes during 2020 in provincial maternal hospital Colestasis intrahepática del embarazo: relación entre niveles de ac. Biliares, transaminasas y bilirrubina con resultados perinatales durante el año 2020 en hospital materno provincial A Crescente , SJC Lopez , AL Gestational Cholestasis Bile acids Pruritus Intrauterine fetal death Colestasis Gestacional Ácidos biliares Prurito Muerte fetal Intraútero . Abstract: Intrahepatic Cholestasis of Pregnancy (ICD) is a pathology associated with serious adverse perinatal outcomes. They include: spontaneous preterm birth, asphyxia or fetal distress, meconium-stained amniotic fluid and intrauterine fetal death. Our objective was to establish rates of adverse perinatal outcomes according to serum bile acids concentrations, transaminases and bilirubin, in patients of the Obstetric Service of the Provincial Maternal Hospital during 2020. Observational, retrospective, cross-sectional and descriptive study. Patients with a confirmed clinical and / or biochemical diagnosis of ICD were evaluated, who received follow-up and completed their pregnancy in the Obstetrics Service of the institution previously mentioned. These patients should have laboratories with serum bile acid concentrations, transaminases and bilirubins, for diagnosis, monitoring and at the time of termination of pregnancy. 38 patients with a diagnosis of ICD were included. An incidence of 1.1 out of 100 live new-borns was established. 44.73% presented low perinatal risk, 23.69% moderate risk, and 31.37% high risk, according to biochemical markers. 33.6% completed their pregnancy at 37 weeks, except for those who presented values> 40 micromol / L, even with treatment, which were completed between 32 and 6.6 weeks. Fetal and neonatal deaths were not recorded. The Apgar score at birth after a minute was of 8 +/- 1 standard deviation, and the Apgar score after 5 minutes was of 9 +/- 0.87 standard deviations. The mean weight of the newborn was 2880 grams. 73.1% did not present meconium-stained amniotic fluid. Spontaneous preterm birth occurred in 10.52% of cases. The gestational age at the end of pregnancy is based on high serum bile acid concentrations, biochemical markers most important, together with serum levels of transaminases, to determine the severity of the pathology, monitor and define the termination of pregnancy. Resumen: La Colestasis Intrahepática del embarazo (CIE) es una patología asociada a graves resultados adversos perinatales. Se incluyen: Parto pretérmino espontáneo. Asfixia o distrés fetal. Tinción meconial. Muerte fetal intrautero. Nuestro objetivo fue establecer tasas de resultados perinatales adversos según concentraciones séricas de ácidos biliares, transaminasas y bilirrubina, en pacientes del Servicio de Obstetricia en Hospital Materno Provincial durante el año 2020. Estudio observacional, retrospectivo, transversal y descriptivo. Se evaluaron pacientes con diagnóstico confirmado clínico y/o bioquímico de CIE, que recibieron seguimiento y finalizaron su gestación en el Servicio de Obstetricia de dicha institución. Estas debian contar con laboratorios con niveles de ácidos biliares, transaminasas y bilirrubinas, para el diagnóstico, seguimiento y al momento de finalización del embarazo. Se incluyeron 38 pacientes con diagnóstico de CIE. Se estableció una incidencia de 1.1 de cada 100 recién nacidos vivos. El 44.73 % presentaron riesgo perinatal bajo, el 23.69 % riesgo moderado y el 31. 37 % riesgo alto, segun marcadores serologicos. El 33,6 % finalizaron su embarazo a las 37 semanas, a excepción de aquellas que presentaron valores > 40 micromol/L, aun con tratamiento, que fueron finalizadas entre las 32 y las 6.6 semanas. No se registraron muertes fetales y neonatales. El Apgar al nacer al minuto fue 8 +/- 1 desvio estandar, y el Apgar a los 5 minutos fue de 9 +/- 0.87 desvios estandar. La media de peso del recién nacido fue de 2880 gramos. El 73.1 % no presentó líquido meconial. El parto pretérmino espontáneo se presentó en el 10.52 % de los casos. La edad gestacional de finalización del embarazo se fundamenta en valores altos de ácidos biliares, parámetro más importante, junto con los niveles séricos de transaminasas, para determinar la gravedad de la patología, realizar seguimiento y definir la finalización del embarazo. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/34919 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |