Pituitary apoplexy in pediatric patients: systematic review

Introduction: Necrosis or hemorrhage associated with pituitary tumors is an infrequent complication. The term pituitary apoplexy is related to the development of an inflammatory process that leads to meningeal irritation and perielar areas. At the pediatric level, pituitary apoplexy is a very rare p...

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Autores principales: Picón Jaimes, Yelson Alejandro, Orozco Chinome , Javier Esteban, López Cepeda, Daniela, Quintana Pájaro, Loraine, Galindo-Velásquez, Hather, Ramos-Villegas, Yancarlos, Ripoll-Zapata, Vanessa, Morales-Núñez, María Angélica, Moscote Salazar , Luis Rafael
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022
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Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/27984
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Sumario:Introduction: Necrosis or hemorrhage associated with pituitary tumors is an infrequent complication. The term pituitary apoplexy is related to the development of an inflammatory process that leads to meningeal irritation and perielar areas. At the pediatric level, pituitary apoplexy is a very rare pathology and little analyzed in the literature. Methods: We carry out a systematic review of cases published internationally. We performed the analysis of 8 cases published in the literature, 5 cases in the male pediatric population (62.5%), and 3 cases in the female gender (37.5%). Results: The mean age was 12.8 years (SD ± 2.5). The clinical manifestations included: headache, impaired vision, nausea and vomiting, fever, cranial nerve involvement and, to a lesser extent, compromise of the state of consciousness. 75% (n = 6) of the patients had headache, 16.6% had frontal localization, 16.6% had retroorbital pain, and 66.6% did not specify the location. On the other hand, only 37.5% of the patients presented nausea and / or vomiting. While 25% entered with fever and 12.5% ​​(n = 1) they had changes in the state of consciousness. Conclusion: Pituitary apoplexy is a pathology that requires a multidisciplinary approach at the pediatric level, the management directed by neurosurgery and pediatric endocrinology will allow us to offer our patients the best, evidence-based treatment available.