Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies
Chronic pain has a marked negative impact on the quality of life. In recent years, it has been increasing interest in the development of new safer more effective treatments of neuropathic pain, which is presented with sensory abnormalities such as allodynia and hyperalgesia. Recent studies ...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/25889 |
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I10-R327-article-25889 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
neuropathic pain analgesic effect of omega 3 fatty acids preclinical trials dolor neuropático periférico ácidos grasos omega-3 estudios pre-clínicos |
| spellingShingle |
neuropathic pain analgesic effect of omega 3 fatty acids preclinical trials dolor neuropático periférico ácidos grasos omega-3 estudios pre-clínicos Elorriaga, FC Unda, SR Villegas, EA Rumañuk, CB Olivera, ME Laino, CH Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| topic_facet |
neuropathic pain analgesic effect of omega 3 fatty acids preclinical trials dolor neuropático periférico ácidos grasos omega-3 estudios pre-clínicos |
| author |
Elorriaga, FC Unda, SR Villegas, EA Rumañuk, CB Olivera, ME Laino, CH |
| author_facet |
Elorriaga, FC Unda, SR Villegas, EA Rumañuk, CB Olivera, ME Laino, CH |
| author_sort |
Elorriaga, FC |
| title |
Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| title_short |
Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| title_full |
Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| title_fullStr |
Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| title_full_unstemmed |
Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| title_sort |
omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies |
| description |
Chronic pain has a marked negative impact on the quality of life. In recent years, it has been increasing interest in the development of new safer more effective treatments of neuropathic pain, which is presented with sensory abnormalities such as allodynia and hyperalgesia. Recent studies have demonstrated the analgesic effect of omega-3 fatty acids (O3). The aim of the present work was to evaluate thermal hyperalgesia, mechanical allodynia and nerve regeneration after treatment with O3 in an animal model of peripheral neuropathic pain of chronic sciatic nerve constriction (CCI).
Thermal hyperalgesia, mechanical allodynia and nerve regeneration were evaluated in male Wistar rats, which were administered with: oral O3 (0.32 or 0.72 g / kg) 24 h after ICC and for 21 days (chronic treatment ), oral saline (control group with ICC), local O3 (10 μl, O3 30%) on the sciatic nerve at the end of tissue constriction (acute treatment) and oral O3 (0.32 or 0.72 g / kg) 24 h after surgery but without ICC for 21 days. The tests of thermal hyperalgesia (Hot Plate Test), mechanical allodynia (Von Frey Test) and the functional motor recovery test (Walking track analysis) were performed on days 3, 7, 14 and 21 post-surgery. In all groups, a neuropathological examination was performed on day 21 post-surgery with or without CCI.
Oral O3 treatment blocked of thermal hyperalgesia, decreased the mechanical allodynia (50%) and allowed for the motor function recovery (100%). In addition, neuropathological examination revealed that the nerves conserved the axonal density and architecture while the CCI control group showed loss of continuity of perineurium, neuroma formation and abundant inflammatory infiltrate. In contrast, local O3 administration failed to modify the parameters tested
Oral administration of O3 relieves thermal hyperalgesia effectively and improves the recovery process in rats with CCI, suggesting that they could constitute a potential treatment for the relief of neuropathic pain in humans, with minimal risk of adverse effects. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/25889 |
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I10-R327-article-258892024-08-27T18:26:34Z Omega-3 fatty acids in the treatment of peripheral neuropathic pain: new pharmacological strategies Los ácidos grasos omega-3 en el tratamiento del dolor neuropático periférico: nuevas estrategias farmacológicas Elorriaga, FC Unda, SR Villegas, EA Rumañuk, CB Olivera, ME Laino, CH neuropathic pain analgesic effect of omega 3 fatty acids preclinical trials dolor neuropático periférico ácidos grasos omega-3 estudios pre-clínicos Chronic pain has a marked negative impact on the quality of life. In recent years, it has been increasing interest in the development of new safer more effective treatments of neuropathic pain, which is presented with sensory abnormalities such as allodynia and hyperalgesia. Recent studies have demonstrated the analgesic effect of omega-3 fatty acids (O3). The aim of the present work was to evaluate thermal hyperalgesia, mechanical allodynia and nerve regeneration after treatment with O3 in an animal model of peripheral neuropathic pain of chronic sciatic nerve constriction (CCI). Thermal hyperalgesia, mechanical allodynia and nerve regeneration were evaluated in male Wistar rats, which were administered with: oral O3 (0.32 or 0.72 g / kg) 24 h after ICC and for 21 days (chronic treatment ), oral saline (control group with ICC), local O3 (10 μl, O3 30%) on the sciatic nerve at the end of tissue constriction (acute treatment) and oral O3 (0.32 or 0.72 g / kg) 24 h after surgery but without ICC for 21 days. The tests of thermal hyperalgesia (Hot Plate Test), mechanical allodynia (Von Frey Test) and the functional motor recovery test (Walking track analysis) were performed on days 3, 7, 14 and 21 post-surgery. In all groups, a neuropathological examination was performed on day 21 post-surgery with or without CCI. Oral O3 treatment blocked of thermal hyperalgesia, decreased the mechanical allodynia (50%) and allowed for the motor function recovery (100%). In addition, neuropathological examination revealed that the nerves conserved the axonal density and architecture while the CCI control group showed loss of continuity of perineurium, neuroma formation and abundant inflammatory infiltrate. In contrast, local O3 administration failed to modify the parameters tested Oral administration of O3 relieves thermal hyperalgesia effectively and improves the recovery process in rats with CCI, suggesting that they could constitute a potential treatment for the relief of neuropathic pain in humans, with minimal risk of adverse effects. El dolor crónico tiene un marcado impacto negativo en la calidad de vida. En los últimos años, ha aumentado el interés por el desarrollo de nuevos tratamientos más eficaces y seguros para el dolor neuropático, que se manifiesta con alteraciones sensoriales como la alodinia e hiperalgesia. Los ácidos grasos omega-3 (O3) han demostrado recientemente un efecto analgésico. El objetivo del presente trabajo fue evaluar hiperalgesia térmica, alodinia mecánica y regeneración nerviosa luego del tratamiento con O3 en un modelo animal de dolor neuropático periférico de constricción crónica del nervio ciático (CCI). La hiperalgesia térmica, alodinia mecánica y regeneración nerviosa se evaluaron en ratas Wistar macho, a las que se les administró: O3 oral (0,32 ó 0,72 g/kg) 24 h después de la CCI y durante 21 días (tratamiento crónico), salina oral (grupo control con CCI), O3 local (10 μl, O3 30%) sobre el nervio ciático al finalizar la constricción tisular (tratamiento agudo) y O3 oral (0,32 ó 0,72 g/kg) 24 h después de la cirugía pero sin CCI por 21 días. Las pruebas de hiperalgesia térmica (Hot Plate Test), alodinia mecánica (Test de Von Frey) y el test funcional de recuperación motora (Walking track analysis) se realizaron los días 3, 7, 14 y 21 postcirugía. En todos los grupos se realizó una exploración neuropatológica el día 21 postcirugía con o sin CCI. En los grupos tratados via oral con O3 se observó una anulación de la hiperalgesia térmica, una disminución (50%) de la alodinia mecánica y una recuperación funcional motora total (100%). Además, la exploración neuropatológica reveló que los nervios conservaron la arquitectura y densidad axonal mientras que, en el grupo control con CCI se identificó pérdida de continuidad del perineuro, formación de neuroma y abundante infiltrado inflamatorio. En contraste, la administración local de O3 no modifico esos parámetros. La administración oral de O3 alivia la hiperalgesia térmica de manera efectiva y mejora el proceso de recuperación en ratas con CCI, sugiriendo que podrían constituir un potencial tratamiento para el alivio del dolor neuropático en humanos, con mínimo riesgo de producir efectos adversos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/25889 Revista de la Facultad de Ciencias Médicas de Córdoba.; 2019: Suplemento JIC XX Revista de la Facultad de Ciencias Médicas de Córdoba; 2019: Suplemento JIC XX Revista da Faculdade de Ciências Médicas de Córdoba; 2019: Suplemento JIC XX 1853-0605 0014-6722 10.31053/1853.0605.v76.nSuplemento spa https://revistas.unc.edu.ar/index.php/med/article/view/25889/27710 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |